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Titolo:
Sensitization of resting T cells to autologous natural-killer-cell-mediated lysis by phytohemagglutinin
Autore:
Baraz, L; Kotler, M; Condiotti, R; Nagler, A;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Pathol, IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel Hadassah Univ Hosp, Bone Marrow Transplantat Dept, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel
Titolo Testata:
CANCER IMMUNOLOGY IMMUNOTHERAPY
fascicolo: 9, volume: 48, anno: 1999,
pagine: 507 - 516
SICI:
0340-7004(199912)48:9<507:SORTCT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX CLASS-I; NK CELLS; LYMPHOCYTES; EXPRESSION; RECEPTORS; SELF; SPECIFICITY; INFECTIONS; ACTIVATION; MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kotler, M Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Pathol, POB 12272,IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem POB 12272 Jerusalem Israel IL-91010 srael
Citazione:
L. Baraz et al., "Sensitization of resting T cells to autologous natural-killer-cell-mediated lysis by phytohemagglutinin", CANCER IMMU, 48(9), 1999, pp. 507-516

Abstract

Natural killer (NK) cells are non-T, non-B cell lymphocytes that lyse a variety of tumor and virus-infected cells. In this study, we demonstrated that phytohemagglutinin (PHA) rendered resistant autologous T cells extremely sensitive to natural-killer(NK)-cell-mediated lysis. The sensitization was very rapid and concentration-dependent (0.01-1 mu g/ml); 62% and 95% of autologous T cells were lysed by interleukin-2-activated NK cells 5 min and 18h respectively after treatment with PHA (1 mu g/ml). The maximal decrease in the level of MHC class I molecules observed on T cells was 22%. Induction of susceptibility to NK-mediated lysis was correlated with the expressionof activation markers on T cells treated:for relatively long intervals (more than 18 h) with high concentrations of PHA (more than 0.1 mu g/ml). Sensitization of T cells required RNA and protein synthesis, although DNA synthesis was not essential. We propose that this unique system is suitable for studying the mechanisms involved in recognition and killing of target cellsby NK cells.

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Documento generato il 04/04/20 alle ore 01:50:23