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Titolo:
Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer
Autore:
Ramesh, S; Nash, J; McCulloch, PG;
Indirizzi:
Univ Liverpool, Dept Surg, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England Univ Liverpool, Dept Pathol, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 8, volume: 81, anno: 1999,
pagine: 1392 - 1397
SICI:
0007-0920(199912)81:8<1392:RIMEOB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; CELL-CELL ADHESION; COLORECTAL-CANCER; IMMUNOHISTOCHEMICAL EVALUATION; ALPHA-CATENIN; HIGH-GRADE; APC GENE; CARCINOMA; MUTATIONS; PROTEIN;
Keywords:
gastric cancer; beta-catenin and survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: McCulloch, PG Univ Liverpool, Dept Surg, 5th Floor,UCD,Daulby St, Liverpool L69 3GA, Merseyside, England Univ Liverpool 5th Floor,UCD,Daulby St Liverpool Merseyside England L69 3GA
Citazione:
S. Ramesh et al., "Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer", BR J CANC, 81(8), 1999, pp. 1392-1397

Abstract

beta-catenin, a component of the E-cadherin-calenin cell adhesion complex,also plays a separate intracellular signalling role, interacting with APC protein. Intracellular accumulation of beta-catenin is common in colorectalneoplasia. beta-catenin abnormalities are associated with poor survival ingastric cancer, but previous studies do not differentiate between membrane-associated and intracellular beta-catenin. In this study we aimed to determine which type of expression abnormalities for E-cadherin, beta-catenin and alpha-catenin correlate with clinico-pathological features and survival in gastric cancer. Immunoperoxidase staining of paraffin-embedded sections from 40 gastric cancers was performed for E-cadherin, alpha- and beta-catenins using microwave unmasking and an avidin-biotin technique. Clinical data were obtained from case records and cancer registry records. Reduced membranous expression of beta-catenin occurred in 10/12 (83%) diffuse and 8/28 (29%) intestinal tumours (P = 0.0014), and was associated with poor differentiation (P = 0.0015) and short survival (P = 0.032), but not with age, sex, tumour size or nodal status. Nuclear expression of beta-catenin was uncommon; cytoplasmic expression was observed in 13/40 cases (33%) but did not correlate with histology, tumour grade or survival. Reduced E-cadherin membrane expression was associated with lymph node metastasis (P = 0.02). Neither E-cadherin or alpha-catenin expression correlated with survival. Reduced membranous expression of beta-catenin predicts poor prognosis in gastric cancer, whilst ectopic intracellular expression is relatively rare. The apparent differences in beta-calenin expression from those found in colon cancer merit further study. (C) 1999 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:52:44