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Titolo:
Serotonin, cerebral blood flow, and cerebral metabolic rate in geriatric major depression and normal aging
Autore:
Nobler, MS; Mann, JJ; Sackeim, HA;
Indirizzi:
New York State Psychiat Inst, Dept Biol Psychiat, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA New York State Psychiat Inst, Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA ys & Surg, Dept Psychiat, New York, NY USA Columbia Univ, Coll Phys & Surg, Dept Radiol, New York, NY USA Columbia Univ New York NY USA Phys & Surg, Dept Radiol, New York, NY USA
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 3, volume: 30, anno: 1999,
pagine: 250 - 263
SICI:
0165-0173(199911)30:3<250:SCBFAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; LATE-LIFE DEPRESSION; PLACEBO-CONTROLLED TRIAL; 5-HT1A RECEPTOR-BINDING; H-3 PAROXETINE BINDING; AGED HUMAN-BRAIN; GLUCOSE-METABOLISM; MOOD DISORDERS; ALZHEIMERS-DISEASE;
Keywords:
serotonin; cerebral blood flow; cerebral metabolic rate; aging; major depressive disorder;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
159
Recensione:
Indirizzi per estratti:
Indirizzo: Nobler, MS New York State Psychiat Inst, Dept Biol Psychiat, 1051 Riverside Dr,Unit 126, New York, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr,Unit 126 New York NY USA 10032
Citazione:
M.S. Nobler et al., "Serotonin, cerebral blood flow, and cerebral metabolic rate in geriatric major depression and normal aging", BRAIN RES R, 30(3), 1999, pp. 250-263

Abstract

While there is substantial evidence for abnormalities in serotonin (5-HT) neurotransmission in major depressive disorder (MDD), almost all of the findings derive from studies of young adults. Moreover, relatively little research has assessed brain 5-HT transmission in vivo. Neuroendocrine studies do not permit evaluation of a range of brain regions, but only the limited circuitry associated with hormone release. Data from autopsy studies are Limited by the difficulties of assessment of the acute clinical picture beforedeath, and by post-mortem artifacts. In vivo neuroimaging techniques overcome many of the methodological limitations of both these approaches. There is a large body df imaging data indicating regional cerebral blood flow (rCBF) and cerebral metabolic rate (rCMR) decrements both with aging and in patients with MDD. While the physiological bases for these phenomena are largely unknown, changes in brain 5-HT function may be involved. Neuroanatomical studies have revealed an intricate network of ti-HT-containing neurons within the cerebral microvasculature, with physiological evidence for serotonergic control of both rCBF and rCMR. Acute pharmacological challenges are available to probe brain 5-HT function. Such paradigms, using neuroendocrineresponses as endpoints, have been of some utility in predicting outcome with antidepressant treatment. The role of 5-HT dysregulation in geriatric MDD takes on more importance given concerns regarding putative reduced efficacy of serotonin-specific reuptake inhibitors (SSRIs) in this population. Ifthis is due to diminished responsivity of 5-HT systems, then the ability to identify antidepressant nonresponders via 5-HT challenge in combination with neuroimaging measures may have important clinical utility. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:37:25