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Titolo:
Mutation analysis of the HFE gene in Brazilian populations
Autore:
Agostinho, MF; Arruda, VR; Basseres, DS; Bordin, S; Soares, MCP; Menezes, RC; Costa, FF; Saad, STO;
Indirizzi:
Univ Estadual Campinas, Fac Ciencias Med, Hemoctr, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil Inst Evandro Chagas, Belem, Para, Brazil Inst Evandro Chagas Belem Para Brazil vandro Chagas, Belem, Para, Brazil
Titolo Testata:
BLOOD CELLS MOLECULES AND DISEASES
fascicolo: 21, volume: 25, anno: 1999,
pagine: 324 - 327
SICI:
1079-9796(19991115)25:21<324:MAOTHG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY HEMOCHROMATOSIS; C282Y MUTATION; PREVALENCE; HLA;
Keywords:
hemochromatosis; HFE gene; Brazilian population; Amerindians; Parakana Indians;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Saad, STO Univ Estadual Campinas, Fac Ciencias Med, Hemoctr, CP6198, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas CP6198 Campinas SP Brazil BR-13083970 BCl
Citazione:
M.F. Agostinho et al., "Mutation analysis of the HFE gene in Brazilian populations", BL CELL M D, 25(21), 1999, pp. 324-327

Abstract

We analyzed the frequency of the C282Y and H63D mutations in the HFE gene in 227 individuals from Brazil comprising 71 Caucasians, 91 racially mixed Caucasian African-derived Amerindians (both populations from Southeast Brazil), 85 African-derived subjects (from Northeast Brazil) and 75 Parakana Indians, Allelic frequency of the mutation C. 845G6A (C282Y) was 1.4% in the Caucasian population, 1.1% in the African-derived population, 1.1% in the racially mixed normal controls and 0% in the Parakana Indians. In the African-derived population, the C282Y mutation was present on chromosomes bearingthe haplotype 6/1h according to Beutler and West (1997). Allelic frequencyof the mutation C. 187C6G (H63D) was 16.3% in the Caucasian population, 7.5% in the African-derived population, 9.8% in the racially mixed controls and 0% in the Amerindians. The presence of these mutations in the African-derived population reflects the fact that these subjects may have undergone anon-identified racial admixture in their past history. The absence of bothdefects in the Amerindians suggests that these mutations have emerged after the migration of Polynesians to America, or that they may not have reached the Polynesian population until after the migration to America had occurred.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 05:45:22