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Titolo:
Improving effect of dietary taurine on marked hypercholesterolemia inducedby a high-cholesterol diet in streptozotocin-induced diabetic rats
Autore:
Mochizuki, H; Takido, J; Oda, H; Yokogoshi, H;
Indirizzi:
Univ Shizouka, Sch Food & Nutr Sci, Shizouka 4228526, Japan Univ ShizoukaShizouka Japan 4228526 & Nutr Sci, Shizouka 4228526, Japan Nagoya Univ, Dept Appl Biol Sci, Nagoya, Aichi 4648601, Japan Nagoya UnivNagoya Aichi Japan 4648601 Sci, Nagoya, Aichi 4648601, Japan
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 11, volume: 63, anno: 1999,
pagine: 1984 - 1987
SICI:
0916-8451(199911)63:11<1984:IEODTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACYL-COA; ACYLTRANSFERASE; METABOLISM;
Keywords:
taurine; hypercholesterolemia; streptozotocin-induced diabetes; CYP7A1 (cholesterol 7 alpha-hydroxylase); rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Yokogoshi, H Univ Shizouka, Sch Food & Nutr Sci, 52-1 Yada, Shizouka 4228526, Japan Univ Shizouka 52-1 Yada Shizouka Japan 4228526 228526, Japan
Citazione:
H. Mochizuki et al., "Improving effect of dietary taurine on marked hypercholesterolemia inducedby a high-cholesterol diet in streptozotocin-induced diabetic rats", BIOS BIOT B, 63(11), 1999, pp. 1984-1987

Abstract

The effect of dietary taurine on hypercholesterolemia induced by a high-cholesterol diet in streptozotocin (STZ)-induced diabetic rats was Investigated. The concentrations of serum and liver cholesterol were markedly elevated in STZ diabetic rats fed on the cholesterol-containing diet, and dietary taurine significantly reduced this elevated level of cholesterol in the serum and liver. The gene expression of cholesterol 7 alpha-hydroxylase (CYP7A1), which is the rate-limiting enzyme for cholesterol degradation, was induced by the supplementation of taurine to the high-cholesterol diet. It is suggested that one of the reasons for this hypocholesterolemic action by taurine might have been the enhancement of cholesterol degradation.

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Documento generato il 01/12/20 alle ore 10:02:27