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Titolo:
Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations
Autore:
Mumby, DG; Astur, RS; Weisend, MP; Sutherland, RJ;
Indirizzi:
Concordia Univ, Dept Psychol, Montreal, PQ H4B 1R6, Canada Concordia UnivMontreal PQ Canada H4B 1R6 l, Montreal, PQ H4B 1R6, Canada Univ New Mexico, Dept Psychol & Neurosci, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 106, anno: 1999,
pagine: 97 - 107
SICI:
0166-4328(199912)106:1-2<97:RAASDT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOGNITION MEMORY; PERIRHINAL CORTEX; IBOTENATE LESIONS; RATS; AMYGDALA; MONKEYS; IMPAIRMENT; COMPONENTS; SUBICULUM; DEFICITS;
Keywords:
retrograde amnesia; spatial memory; object discrimination; hippocampal formation; consolidation; water maze; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mumby, DG Concordia Univ, Dept Psychol, DS-413,7141 Sherbrooke St W, Montreal, PQ H4B 1R6, Canada Concordia Univ DS-413,7141 Sherbrooke St W MontrealPQ Canada H4B 1R6
Citazione:
D.G. Mumby et al., "Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations", BEH BRA RES, 106(1-2), 1999, pp. 97-107

Abstract

Using a within-subjects design, rats were trained on two place-memory problems and five object-discrimination problems at different intervals prior to receiving either ibotenate lesions of the hippocampal formation or sham surgery. Places # 1 and 2 were fixed-platform water-maze tasks that were runin different rooms and they were learned during the 14th and 2nd week before surgery, respectively. Object-discrimination problems #1-5 were learned during the 13th, 10th, 7th, 4th, and Ist week before surgery, respectively. Rats with hippocampal lesions displayed impaired retention of both Place problems with no evidence of a temporal gradient to the impairment. In contrast to their retrograde place-memory deficits, the hippocampal rats displayed normal retention of the five object-discriminations that were learned before surgery. Hippocampal lesions had similar consequences for anterograde learning, as the lesioned rats were impaired in acquisition of a new water-maze problem that was run in a third room (Place #3), whereas they showed normal acquisition of two new object-discriminations. The findings indicate that the hippocampal formation is not required for long-term consolidation of information underlying accurate performance of object-discriminations, and that its critical role in memory for places persists for at least 14 weeks, and probably for as long as those memories exist. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 23/01/20 alle ore 19:06:46