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Titolo:
Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats
Autore:
Dunnett, SB; Nathwani, F; Brasted, PJ;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY hol, Cambridge CB2 2PY, England
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 106, anno: 1999,
pagine: 13 - 28
SICI:
0166-4328(199912)106:1-2<13:MPANLD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM-MEMORY; SPATIAL RESPONSE ALTERNATION; POSITION TASK; WORKING-MEMORY; CORTEX LESIONS; BEHAVIORAL DEFICITS; NEUROTOXIC LESIONS; CHOLINERGIC DRUGS; SEPTAL-LESIONS; BASAL GANGLIA;
Keywords:
prefrontal cortex; neostriatum; frontostriatal systems; delayed alternation; operant tests; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Dunnett, SB Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Downing St, Cambridge CB22PY, England Univ Cambridge Downing St Cambridge England CB2 2PY , England
Citazione:
S.B. Dunnett et al., "Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats", BEH BRA RES, 106(1-2), 1999, pp. 13-28

Abstract

An operant version of the classical delayed alternation task is presented and applied to evaluate the effects of bilateral prefrontal and striatal lesions in rats. Retractable levers in a conventional operant chamber controldiscrete trial opportunities for making sequential choice responses to thetwo sides, and the rats are required to maintain repeated nose poke responses to a central panel during the delay interval, which is randomly varied. The operant task provides measures of the speed and accuracy of response alternation and side bias; analysis at different delay intervals provides anindex of the memory demands of accurate performance; and analysis of accuracy depending on the response on preceding trials provides measures of proactive interference and perseveration. Following pretraining in the task contingencies, both striatal and prefrontal lesions induced profound deficits in task accuracy, with no change in side bias and only small changes in movement times. The deficit in the prefrontal lesion group recovered more rapidly, neither group showed any change in sensitivity to proactive interference, while the rats with striatal lesions alone exhibited an increased tendency to perseverate incorrect responses on either side. We conclude that theoperant delayed alternation task should assist analysis of fronto-striatalfunction in rats as well as be useful for the analysis of strategies for fronto-striatal repair. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:24:41