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Titolo:
Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins lessons from twin studies
Autore:
Snieder, H; van Doornen, LJP; Boomsma, DI;
Indirizzi:
Vrije Univ Amsterdam, Dept Psychophysiol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands siol, Amsterdam, Netherlands
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 12, volume: 19, anno: 1999,
pagine: 2826 - 2834
SICI:
1079-5642(199912)19:12<2826:DTGAOL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; HIGH-DENSITY LIPOPROTEIN; QUANTITATIVE TRAIT LOCI; RISK FACTOR VARIABLES; ADULT FEMALE TWINS; CARDIOVASCULAR-DISEASE; SERUM-CHOLESTEROL; WOMEN TWINS; HDL CHOLESTEROL; BLOOD-PRESSURE;
Keywords:
lipids; genetics; twin studies; age; pleiotropy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Snieder, H St Thomas Hosp, Twin Res Unit, Lambeth Palace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH ngland
Citazione:
H. Snieder et al., "Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins lessons from twin studies", ART THROM V, 19(12), 1999, pp. 2826-2834

Abstract

We review the ways in which twin studies have been used to investigate thegenetic architecture of lipids, lipoproteins, and apolipoproteins. We focus on the age dependency of genetic effects and the importance of pleiotropyfor the lipid system. Finally, consequences are discussed of age dependency and pleiotropy for the design and power of twin studies aimed at detecting the actual quantitative trait loci (QTLs) involved. It is concluded that twin studies have played an important role and will remain highly valuable for the elucidation of the genetic architecture of lipids, lipoproteins, and apolipoproteins. Twins can efficiently be used to identify the location and function of QTLs. Taking account of pleiotropy and age-dependent gene expression in study design and data analysis will improve the power and efficiency to find these QTLs for components of the lipid system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:09:38