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Titolo:
Proteoglycan and collagen biochemical variations during fluoroquinolone-induced chondrotoxicity in mice
Autore:
Simonin, MA; Gegout-Pottie, P; Minn, A; Gillet, P; Netter, P; Terlain, B;
Indirizzi:
Univ Nancy 1, Fac Med, CNRS,Dept Pharmacol, UMR Physiopathol & Pharmacol Articulaires 7561, F-54505 Vandoeuvre Nancy, France Univ Nancy 1 VandoeuvreNancy France F-54505 05 Vandoeuvre Nancy, France
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 12, volume: 43, anno: 1999,
pagine: 2915 - 2921
SICI:
0066-4804(199912)43:12<2915:PACBVD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUINOLONE-INDUCED ARTHROPATHY; HUMAN DERMAL FIBROBLASTS; ARTICULAR-CARTILAGE; INORGANIC SULFATE; MAGNESIUM-DEFICIENCY; ANTIMICROBIAL AGENTS; CROSS-LINKING; IN-VITRO; CHONDROCYTES; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Netter, P Univ Nancy 1, Fac Med, CNRS,Dept Pharmacol, UMR Physiopathol & Pharmacol Articulaires 7561, Ave Foret de Haye,BP 184, F-54505 Vandoeuvre Nancy, France Univ Nancy 1 Ave Foret de Haye,BP 184 Vandoeuvre Nancy France F-54505
Citazione:
M.A. Simonin et al., "Proteoglycan and collagen biochemical variations during fluoroquinolone-induced chondrotoxicity in mice", ANTIM AG CH, 43(12), 1999, pp. 2915-2921

Abstract

Although fluoroquinolone antibacterials have a broad therapeutic use, witha relatively low incidence of severe side effects, they have been reportedto induce Lesions in the cartilage of growing animals by a mechanism that remains unclear. This study was undertaken to determine the potentially deleterious effect of a high dose of pefloxacin (400 mg/kg of body weight) on two main constituents of cartilage in mice, i.e,, proteoglycans and collagen. Variations in levels of proteoglycan anabolism measured by in vivo [S-35]sulfate incorporation into cartilage and oxidative modifications of collagen assessed by detection of carbonyl derivatives were monitored after administration of pefloxacin. Treatment of mice with 1 day of pefloxacin treatment significantly decreased the rate of biosynthesis of proteoglycan for thefirst 24 h, However, no difference was observed after 48 h, The decrease in proteoglycan synthesis was accompanied by a marked drop in serum sulfate concentration and a concomitant increase in urinary sulfate excretion. The decrease in proteoglycan synthesis, also observed ex vivo, may suggest a direct effect of pefloxacin on this process, rather than it being a consequence of a low concentration of sulfate. On the other hand, treatment with pefloxacin for 10 days induced oxidative damage to collagen. In conclusion, this study demonstrates, for the first time, that pefloxacin administration to mice leads to modifications in the metabolism and integrity of extracellular proteins, such as collagen and proteoglycans, which may account for theside effects observed. These results offer new insights to explain quinolone-induced disorders in growing articular cartilage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 16:00:01