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Titolo:
The loss of p27 protein has an independent prognostic significance in gastric cancer
Autore:
Kwon, OJ; Kang, HS; Suh, JS; Chang, MS; Jang, JJ; Chung, JK;
Indirizzi:
Seoul Natl Univ Hosp, Dept Pathol, Boramae City Hosp, Seoul 156012, South Korea Seoul Natl Univ Hosp Seoul South Korea 156012 Seoul 156012, South Korea Seoul Natl Univ Hosp, Dept Surg, Boramae City Hosp, Seoul 156012, South Korea Seoul Natl Univ Hosp Seoul South Korea 156012 Seoul 156012, South Korea
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5B, volume: 19, anno: 1999,
pagine: 4215 - 4220
SICI:
0250-7005(199909/10)19:5B<4215:TLOPPH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEASOME PATHWAY; LYMPH-NODE DISSECTION; KINASE INHIBITOR P27; CYCLIN-E; BREAST-CANCER; CELL-CYCLE; COLORECTAL CARCINOMAS; P27(KIP1); AMPLIFICATION; MARKER;
Keywords:
gastric cancer; prognostic factor; p27; cyclin E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, JK Boramae City Hosp, Dept Surg, 395 Sindaebang Dong, Seoul 110744,South Korea Boramae City Hosp 395 Sindaebang Dong Seoul South Korea 110744
Citazione:
O.J. Kwon et al., "The loss of p27 protein has an independent prognostic significance in gastric cancer", ANTICANC R, 19(5B), 1999, pp. 4215-4220

Abstract

Background: p27 and cyclin E are regulators of the G1 to S phase transition. This study was performed to determine whether two cell cycle regulators-p27 and cyclin E- provided prognostic information in gastric cancer patients. Materials and Methods: A total of 115 gastric cancer patients were eligible for this study from Jan. 1988 through Dec. 1994, and their paraffin blocks were chosen for immunohistochemical staining against p27 and cyclin E. Results: Consequently, 35 patients were stained positively for p27 (30.4%) and 24 for cyclin E (20.9%). A high level of p27 expression was more frequently observed in intestinal type (43.9%) than in diffuse (23.0%) (p=0.019). Concerning patients' survival, univariate analysis showed that the depth of invasion (p=0.043), the number of metastatic nodes (p=0.024) and the expression of p27 (p=0.031) were significant prognostic factors. In particular,p27 negative group showed a worse overall survival than their counterpart (42.42+/-9.63% Vs 26.63+/-4.17%). On multivariate analysis by Cox regression model, the expression of p27 (p=0.048) and number of metastatic nodes (p=0.026) were significant prognostic factors on overall survival. Conclusions: Loss of the p27 protein has independent prognostic significance in gastric carcinomas, and whether p27 negative gastric cancer requires more radicaltherapies can be elucidated by future clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:58:30