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Titolo:
A sensitive immunofluorescence assay for detection of p53 protein accumulation in sputum
Autore:
Feng, ZM; Tian, DF; Lan, Q; Mumford, JL;
Indirizzi:
US EPA, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711US EPA, Res Triangle Pk, NC 27711 USA Univ N Carolina, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NCUSA 27599 olina, Chapel Hill, NC 27599 USA
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5B, volume: 19, anno: 1999,
pagine: 3847 - 3852
SICI:
0250-7005(199909/10)19:5B<3847:ASIAFD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; HUMAN-LUNG-CANCER; CLINICAL IMPLICATIONS; EXPRESSION; DIAGNOSIS; ANTIGEN; CELLS;
Keywords:
lung cancer; sputum; p53 protein accumulation; immunofluorescence assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Feng, ZM US EPA, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Triangle Pk, NC 27711 USA
Citazione:
Z.M. Feng et al., "A sensitive immunofluorescence assay for detection of p53 protein accumulation in sputum", ANTICANC R, 19(5B), 1999, pp. 3847-3852

Abstract

p53 mutations are common genetic alterations in lung cancels and usually, result in p53 protein accumulation in tumor cells. Sputum is noninvasive tocollect and ideal for screening p53 abnormalities. This study was to determine the feasibility of detecting p53 protein accumulation in sputum cells rising an immunofluorescence assay. Sputum samples were collected from 58 Chinese subjects, including 16 lung cancer cases from Xuan Wei (XW) County exposed to coal smoke, 25 mostly tobacco smoke-related cases from Zhengzhou City and 17 XW controls. The p53 protein accumulation in tumor cells and some atypical cells was detected in 56% (9/16) of the coal smoke-exposed XW cases, 44% (11/25) of the Zhengzhou cases and none (0/17) in controls. The p53+ tumor cells were confirmed morphologically by Papanicolaou staining after the p53 immunofluorescence assay. This is the first leper? of successfully using an immunofluorescence assay to detect p53 protein accumulation in sputum.

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Documento generato il 25/01/21 alle ore 16:07:48