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Titolo:
Systemic amyloidosis presenting with angina pectoris
Autore:
Al Suwaidi, J; Velianou, JL; Gertz, MA; Cannon, RO; Higano, ST; Holmes, DR; Lerman, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Hematol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 atol, Rochester, MN 55905 USA NHLBI, NIH, Cardiol Branch, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 , NIH, Cardiol Branch, Bethesda, MD 20892 USA
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 11, volume: 131, anno: 1999,
pagine: 838 - 841
SICI:
0003-4819(199912)131:11<838:SAPWAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; CARDIAC AMYLOIDOSIS; CHEST PAIN; CORONARY; ARTERIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 05 USA
Citazione:
J. Al Suwaidi et al., "Systemic amyloidosis presenting with angina pectoris", ANN INT MED, 131(11), 1999, pp. 838-841

Abstract

Background: Manifestations of cardiac amyloidosis may include congestive heart failure and sudden cardiac death. Although vascular involvement in patients with amyloidosis is common, systemic amyloidosis presenting with angina is rare. Objectives: To report on patients with systemic amyloidosis presenting with angina pectoris. Design: Case series. Setting: Academic medical center. Patients: Five patients who presented with angina pectoris and normal coronary angiogram as the initial manifestation of systemic amyloidosis. Measurements: Endothelial-dependent and endothelialin-dependent coronary flow reserve. Results: All patients had coronary flow reserve abnormalities and subsequently developed congestive heart failure and systemic manifestations of amyloidosis. Histologic evaluation revealed amyloid deposition in the intramyocardial coronary vessels. Conclusions: Cardiac amyloidosis can present as angina pectoris associatedwith coronary flow reserve abnormalities despite normal coronary angiograms. This finding may have major therapeutic and prognostic implications in this patient population.

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Documento generato il 15/07/20 alle ore 15:02:55