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Titolo:
Novel polymorphism in the promoter and coding regions of the human cholecystokinin B receptor gene: An association analysis with schizophrenia
Autore:
Tachikawa, H; Harada, S; Kawanishi, Y; Okubo, T; Shiraishi, H;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 y Med, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 6, volume: 88, anno: 1999,
pagine: 700 - 704
SICI:
0148-7299(199912)88:6<700:NPITPA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANIC DISORDER; LIMBIC LOBE; HUMAN BRAIN; DOPAMINE; CLONING; CCKB;
Keywords:
genetic variation; association analysis; clinical heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tachikawa, H Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 3058575 an
Citazione:
H. Tachikawa et al., "Novel polymorphism in the promoter and coding regions of the human cholecystokinin B receptor gene: An association analysis with schizophrenia", AM J MED G, 88(6), 1999, pp. 700-704

Abstract

Genetic variations in the 5'-untranslated region and the coding region of the CCK-B receptor (CCK-BR) gene were investigated in healthy controls. Novel variants (-215 C-->A, Leu37Phe, Arg319Glu) were found in addition to themutations (Val125Iso, His207His, Arg215His, 2491 C-->A) reported previously. In the present study, association analysis was carried out for these variants between 80 unrelated schizophrenic patients and 100 healthy controls. The genotype frequency of the -215 C-->A nucleotide substitution in the 5'-untranslated region of CCK-BR gene was significantly higher in the schizophrenic patients than in the controls (6.25%, P = 0.037), However, the difference was not significant after Bonferrolli correction for multiple comparisons. Moreover, no association was found between the clinical characteristics of the patients and the genotype frequencies of the variants. These results suggest that the CCK-BR gene polymorphisms have no association with schizophrenia nor its clinical heterogeneity. Am. J. Med, Genet. (Neuropsychiatr, Genet.) 88:700-704, 1999. (C) 1999 Wiley-Liss Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:31:46