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Titolo:
Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion
Autore:
Faraone, SV; Meyer, J; Matise, T; Svrakic, D; Pepple, J; Malaspina, D; Suarez, B; Hampe, C; Chan, G; Aelony, A; Friedman, JH; Kaufmann, C; Cloninger, CR; Tsuang, MT;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Ctr, Dept Psychiat, Boston, MA 02115 USA Brockton W Roxbury Vet Affairs Med Ctr, Brockton, MA USA Brockton W Roxbury Vet Affairs Med Ctr Brockton MA USA Brockton, MA USA Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 iat Serv, Boston, MA 02114 USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Epidemiol & Genet, Boston, MA 02115 USA Millennium Pharmaceut, Cambridge, MA USA Millennium Pharmaceut Cambridge MA USA ium Pharmaceut, Cambridge, MA USA Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA Rockefeller UnivNew York NY USA 10021 Stat Genet, New York, NY 10021 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Columbia Univ, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA mbia Univ, Dept Psychiat, New York, NY USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 6, volume: 88, anno: 1999,
pagine: 607 - 608
SICI:
0148-7299(199912)88:6<607:SLOC1T>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILLENNIUM-CONSORTIUM; GENOME SCAN; PEDIGREES; LOCUS;
Keywords:
schizophrenia; linkage; transmission ratio distortion; chromosome 10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Faraone, SV Harvard Univ, Sch Med, Suite 255,750 Washington St, S Easton, MA 02375 USA Harvard Univ Suite 255,750 Washington St S Easton MA USA 02375
Citazione:
S.V. Faraone et al., "Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion", AM J MED G, 88(6), 1999, pp. 607-608

Abstract

The genome scan of the European-American schizophrenia families from the Human Genetics Initiative of the National Institute of Mental Health (NIMH) reported a suggestive linkage to chromosome 10p. Subsequently, Paterson andPetronis [1999] reported evidence for transmission ratio distortion on 10pto females. They suggested that transmission ratio distortion to females might have created spurious evidence for linkage to 10p. To address this issue, we reanalyzed our 10p data using only male-male affected sibling pairs. The two chromosome 10p markers that gave the most evidence for linkage in our prior report continued to show evidence for linkage: D10S1423 (NPL Z = 3.0, P = 0.001) and its neighbor D10S582 (NPL Z = 2.9, P = 0.002). These data suggest that our prior report of suggestive linkage of schizophrenia to markers on 10p cannot be attributed to the transmission ratio distortion tofemales reported by Paterson and Petronis. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:607-608, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 01/04/20 alle ore 17:59:41