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Titolo:
Pharmacoeconomics of antimicrobial therapy
Autore:
Paladino, JA;
Indirizzi:
SUNY Buffalo, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260SUNY Buffalo, Buffalo, NY 14260 USA Millard Fillmore Suburban Hosp, Williamsville, NY 14221 USA Millard Fillmore Suburban Hosp Williamsville NY USA 14221 e, NY 14221 USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
, volume: 56, anno: 1999, supplemento:, 3
pagine: S25 - S28
SICI:
1079-2082(19991115)56:<S25:POAT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUAL INDIVIDUALIZATION PRINCIPLES; COMMUNITY-ACQUIRED PNEUMONIA; INTRAVENOUS CIPROFLOXACIN; MATHEMATICAL EXAMINATION; COST-EFFECTIVENESS; INHIBITORY CURVE; ILL-PATIENTS; CEFMENOXIME; PHARMACODYNAMICS; ANTIBIOTICS;
Keywords:
anti-infective agents; costs; dosage schedules; drug administration routes; pharmacodynamics; pharmacoeconomics; pharmacokinetics; quinolones; respiratory-tract infections; substitution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Paladino, JA SUNY Buffalo, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 alo, Buffalo, NY 14260 USA
Citazione:
J.A. Paladino, "Pharmacoeconomics of antimicrobial therapy", AM J HEAL S, 56, 1999, pp. S25-S28

Abstract

Switch therapy, sequential therapy, and step-down therapy are discussed interms of their contribution to reducing antimicrobial expenditures. Pharmacoeconomics is the science used to identify and compare the costs and consequences of drug therapy in terms of efficacy, safety, and overall health care. Pharmacoeconomic studies of antimicrobials for respiratory-tractinfections have identified significant cost savings associated with regimens that are optimized for a particular patient on the basis of a drug's pharmacokinetic profile. For fluoroquinolones, optimal therapy has been associated with targeting the specific pharmacodynamic variable known as the ratio of the area under the serum concentration-time curve from 0 to 24 hours (AUC) to the minimum inhibitory concentration, also referred to as the area under the inhibitory curve (AUIC). Several studies have shown that regimensthat achieve targeted AUIC values of 125 to 250 against gram-negative aerobic bacteria are cost-effective; cost savings are linked to decreased time to bacterial eradication and higher AUICs. Additional cost-effective measures for hospitals and health care institutions include the implementation offormalized i.v.-to-oral conversions and streamlining programs. Pharmacoeconomic analysis of therapies for respiratory-tract and other infections demonstrates that reducing health care costs may best be achieved by curing the infection in the shortest possible time through dosage optimization individualized to the patient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:53:32