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Titolo:
Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome
Autore:
Sanudo-Pena, MC; Force, M; Kang, T; McLemore, G; Roberts, L; Walker, JM;
Indirizzi:
Brown Univ, Dept Psychol, Schrier Res Lab, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 rier Res Lab, Providence, RI 02912 USA Brown Univ, Dept Neurosci, Schrier Res Lab, Providence, RI 02912 USA BrownUniv Providence RI USA 02912 rier Res Lab, Providence, RI 02912 USA
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 12, volume: 20, anno: 1999,
pagine: 1121 - 1124
SICI:
0253-9756(199912)20:12<1121:DSDNPA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; SR 141716A; DELTA(9)-TETRAHYDROCANNABINOL;
Keywords:
cannabinoids; tetrahydrocannabinol; SR141116A; substance withdrawal syndrome; dopamine D-1 receptors; dopamine D-2 receptors; dopamine antagonists; pruritus; pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Sanudo-Pena, MC Brown Univ, Dept Psychol, Schrier Res Lab, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ovidence, RI 02912 USA
Citazione:
M.C. Sanudo-Pena et al., "Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome", ACT PHAR SI, 20(12), 1999, pp. 1121-1124

Abstract

AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D-1 receptor antagonist SCH23390 or the dopamine D-2 receptor antagonist sulpiride was administeredto rats chronically treated with either ag-tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle sind behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:28:02