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Titolo:
Antagonistic effect of l-stepholidine on striatal ischemic injury in rat
Autore:
Tang, FM; Ding, YM; Chen, YT; Sun, YF; Wang, R; Zhang, GY; Jin, GZ;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Xuzhou 221002, Peoples R China Xuzhou Med Coll Xuzhou Peoples R China 221002 ou 221002, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 12, volume: 20, anno: 1999,
pagine: 1073 - 1078
SICI:
0253-9756(199912)20:12<1073:AEOLOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; PROTEIN-KINASE; DOPAMINE; RECEPTORS; NEURONS; DAMAGE; BRAIN;
Keywords:
dopamine; stepholidine; corpus striatum; cerebral ischemia; Ca2+-calmodulin dependent protein kinase; lactate dehydrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, GZ Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 Peoples R China
Citazione:
F.M. Tang et al., "Antagonistic effect of l-stepholidine on striatal ischemic injury in rat", ACT PHAR SI, 20(12), 1999, pp. 1073-1078

Abstract

AIM: To elucidate the protection of l-stepholidine (SPD) on neuronal morphology and function against the striatal ischemic injury in rat. METHODS: The forebrain ishemia to Sprague Dawley rats was induced with four-vessel occlusion. Histological examination was performed on the dorsolateral striatumwith cresyl-violet stain. In striatal slices of rat as an in vitro ischemic model, the activity of calcium/calmodulin-dependent protein kinase II (CCDPK) and lactate dehydrogenase (LDH) was examined by the method of P-32-incorporation and colorimetry, respectively. RESULTS: In the SPD-treated groups, most of the neurons in the striatum kept the normal morphological appearance after 30-min ischemia followed by 6-h or 12-h reperfusion. The number of neurons was much more in SPD groups than that in vehicle group. The sparse and abnormal neurons were observed in the vehicle group. SPD attenuated the ischemic effect on the CCDPK activity in striatal slices. In addition, SPD inhibited the leakage of LDH from neurons induced by ischemia in incubated striatal slices. CONCLUSION: SPD protected striatal neurons against ischemic injury and antagonized the inhibitory action on CCDPK activity induced by ischemia. SPD reduced the leakage of LDH from striatal neurons inducedby ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:34:53