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Titolo:
Overexpression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: An immunohistochemical analysis of 34 cases
Autore:
Merryman, JI; Buckles, EL; Bowers, G; Neilsen, NR;
Indirizzi:
Univ Tennessee, Coll Vet Med, Dept Pathol, Knoxville, TN 37901 USA Univ Tennessee Knoxville TN USA 37901 ept Pathol, Knoxville, TN 37901 USA
Titolo Testata:
VETERINARY PATHOLOGY
fascicolo: 2, volume: 36, anno: 1999,
pagine: 117 - 124
SICI:
0300-9858(199903)36:2<117:OOCIHA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOMIC INSTABILITY; NODULAR GOITER; CELL-CYCLE; CANCER; HYPERTHYROIDISM; PATHOGENESIS; REGULATORS; MECHANISMS; PROTEINS; REPAIR;
Keywords:
carcinogenesis; cats; c-ras; hyperthyroidism; neoplasia; thyroid follicular adenoma; thyroid glands; thyroid nodular follicular hyperplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Merryman, JI Univ Tennessee, Coll Vet Med, Dept Pathol, POB 1071, Knoxville, TN 37901 USA Univ Tennessee POB 1071 Knoxville TN USA 37901 , TN 37901 USA
Citazione:
J.I. Merryman et al., "Overexpression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: An immunohistochemical analysis of 34 cases", VET PATH, 36(2), 1999, pp. 117-124

Abstract

Formalin-fixed, paraffin-embedded thyroid glands from 18 cats diagnosed with hyperthyroidism were evaluated immunohistochemically for overexpression of the products of oncogenes c-ras and bc12 and the tumor suppressor gene p53. Fourteen thyroid glands from euthyroid cats without histologically detectable thyroid lesions were examined similarly as controls. Results from these investigations showed that all cases of nodular follicular hyperplasia/adenomas stained positively for overexpression of c-Ras protein using a mouse monoclonal anti-human pan-Ras antibody. The most intensely positively staining regions were in luminal cells surrounding abortive follicles. Subjacent thyroid and parathyroid glands from euthyroid cats did not stain immunohistochemically for pan-Pas. There was no detectable staining for either Bcl2 or p53 in any of the cats. These results indicated that overexpression of c-ras was highly associated with areas of nodular follicular hyperplasia/adenomas of feline thyroid glands, and mutations in this oncogene may play a role in the etiopathogenesis of hyperthyroidism in cats.

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Documento generato il 23/09/20 alle ore 12:49:52