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Titolo:
Large-scale applications of NAD(P)-dependent oxidoreductases: recent developments
Autore:
Hummel, W;
Indirizzi:
Univ Dusseldorf, Inst Enzymtechnol, Forschungszentrum Julich, D-52404 Julich, Germany Univ Dusseldorf Julich Germany D-52404 m Julich, D-52404 Julich, Germany
Titolo Testata:
TRENDS IN BIOTECHNOLOGY
fascicolo: 12, volume: 17, anno: 1999,
pagine: 487 - 492
SICI:
0167-7799(199912)17:12<487:LAONOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-PHENYLALANINE DEHYDROGENASE; L-LACTATE DEHYDROGENASE; STEREOSPECIFIC REDUCTION; 2-KETOCARBOXYLIC ACIDS; ALCOHOL-DEHYDROGENASE; SUBSTRATE-SPECIFICITY; FORMATE DEHYDROGENASE; ESCHERICHIA-COLI; ENZYME; R(+)-PHENYLETHANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hummel, W Univ Dusseldorf, Inst Enzymtechnol, Forschungszentrum Julich, POB 2050, D-52404 Julich, Germany Univ Dusseldorf POB 2050 Julich Germany D-52404 Julich, Germany
Citazione:
W. Hummel, "Large-scale applications of NAD(P)-dependent oxidoreductases: recent developments", TRENDS BIOT, 17(12), 1999, pp. 487-492

Abstract

NAD(P)-dependent dehydrogenases are useful catalysts for the synthesis of chiral compounds. Many active and stable enzymes are available that (with high enantioselectivity) reduce ketones or keto acids to chiral alcohols, hydroxy acids or amino acids. Far economic reasons. these reactions need coupling to the simultaneous regeneration of NAD(P)H. For preparative applications, three components have to be combined: an appropriate enzyme, an efficient coenzyme-regenerating step and a suitable reaction-engineering technique.

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Documento generato il 25/09/20 alle ore 00:31:49