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Titolo:
Requirement for B cell linker protein (BLNK) in B cell development
Autore:
Pappu, R; Cheng, AM; Li, B; Gong, Q; Chiu, C; Griffin, N; White, M; Sleckman, BP; Chan, AC;
Indirizzi:
Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Ctr Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Div Rheumatol, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 v Rheumatol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 d, Dept Med, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pathol, St Louis, MO 63110 USA Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 es Med Inst, St Louis, MO 63110 USA
Titolo Testata:
SCIENCE
fascicolo: 5446, volume: 286, anno: 1999,
pagine: 1949 - 1954
SICI:
0036-8075(199912)286:5446<1949:RFBCLP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; SYK TYROSINE KINASE; POSITIVE SELECTION; MICE LACKING; AGAMMAGLOBULINEMIA; ZAP-70; GENE; BTK; DEFICIENCY; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, AC Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 ol, St Louis, MO 63110 USA
Citazione:
R. Pappu et al., "Requirement for B cell linker protein (BLNK) in B cell development", SCIENCE, 286(5446), 1999, pp. 1949-1954

Abstract

Linker proteins function as molecular scaffolds to Localize enzymes with substrates. In B cells, B cell Linker protein (BLNK) Links the B cell receptor (BCR)activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of BLNK, mice deficient in BLNK were generated. B cell development in BLNK-/- mice was blocked at the transition from B220(+) CD43(+) progenitor B to B220(+) CD43(-) precursor B cells. Only a small percentage of immunoglobulin M++ (IgM(++)), but not mature IgM(lo)lgD(hi), B cells were detected in the periphery. Hence, BLNK is anessential component of BCR signaling pathways and is required to promote Bcell development.

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Documento generato il 27/11/20 alle ore 06:27:57