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Titolo:
An alternative pathway for rod signals in the rodent retina: Rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors
Autore:
Hack, I; Peichl, L; Brandstatter, JH;
Indirizzi:
Max Planck Inst Hirnforsch, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 24, volume: 96, anno: 1999,
pagine: 14130 - 14135
SICI:
0027-8424(19991123)96:24<14130:AAPFRS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN RETINA; RAT RETINA; FUNCTIONAL ARCHITECTURE; SYNAPTIC DISTRIBUTION; PLEXIFORM LAYER; GANGLION-CELLS; CAT RETINA; DIVERSITY; ANTIBODY; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brandstatter, JH Max Planck Inst Hirnforsch, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Deutschordenstr 46 Frankfurt Germany D-60528
Citazione:
I. Hack et al., "An alternative pathway for rod signals in the rodent retina: Rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors", P NAS US, 96(24), 1999, pp. 14130-14135

Abstract

In the mammalian retina, extensive processing of spatiotemporal and chromatic information occurs. One key principle in signal transfer through the retina is parallel processing. Two of these parallel pathways are the ON- andOFF-channels transmitting light and dark signals. This dual system is created in the outer plexiform layer, the first relay station in retinal signaltransfer. Photoreceptors release glutamate onto ON- and OFF-type bipolar cells, which are functionally distinguished by their postsynaptic expressionof different types of glutamate receptors, namely ionotropic and metabotropic glutamate receptors. in the current concept, rad photoreceptors connectonly to rod bipolar cells (ON-type) and cone photoreceptors connect only to cone bipolar cells (ON- and OFF-type). We have studied the distribution of (RS)-alpha-aminoJhydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor subunits at the synapses in the auter plexiform layer of the rodent retina by immunoelectron microscopy and serial section reconstruction. We report a non-classical synaptic contact and an alternative pathway forrod signals in the retina. Rod photoreceptors made synaptic contact with putative OFF-cone bipolar cells that expressed the AMPA glutamate receptor subunits GluR1 and GluR2 on their dendrites. Thus, in the retina of mouse and rat, an alternative pathway for rod signals exists, where rod photoreceptors bypass the rod bipolar cell and directly excite OFF-cone bipolar cells through an ionotropic sign conserving AMPA glutamate receptor.

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Documento generato il 10/07/20 alle ore 03:15:46