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Titolo:
Altered emotional and locomotor responses in mice deficient in the transcription factor CREM
Autore:
Maldonado, R; Smadja, C; Mazucchelli, C; Sassone-Corsi, P;
Indirizzi:
Univ Paris 05, CNRS, Dept Pharmacol Mol & Struct, INSERM,U266,URA D1500, F-75270 Paris, France Univ Paris 05 Paris France F-75270 U266,URA D1500, F-75270 Paris, France Univ Strasbourg 1, CNRS, Inst Genet & Biol Mol & Cellulaire, INSERM, F-67404 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67404 , F-67404 Strasbourg, France
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 24, volume: 96, anno: 1999,
pagine: 14094 - 14099
SICI:
0027-8424(19991123)96:24<14094:AEALRI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; LEARNED CONDITIONED-SUPPRESSION; CORTICOTROPIN-RELEASING FACTOR; ELEVATED PLUS-MAZE; GENE-EXPRESSION; SUPRACHIASMATIC NUCLEUS; RHYTHMIC EXPRESSION; PINEAL-GLAND; CAMP; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Maldonado, R Univ Pompeu Fabra, Dept Neurofarmacol, Fac Ciencias Salud & Vida, C DoctorAiguader 80, Barcelona 08003, Spain Univ Pompeu Fabra C DoctorAiguader 80 Barcelona Spain 08003
Citazione:
R. Maldonado et al., "Altered emotional and locomotor responses in mice deficient in the transcription factor CREM", P NAS US, 96(24), 1999, pp. 14094-14099

Abstract

Various transcription factors act as nuclear effecters of the cAMP-dependent signaling pathway. These are the products of three genes in the mouse, CREB, CRE modulator (CREM), and ATF-1. CREM proteins are thought to play important roles within the hypothalamic-pituitary axis and in the control of rhythmic functions in the pineal gland. We have generated CREM-mutant mice and investigated their response in a variety of behavioral tests. CREM-null mice show a drastic increase in locomotion. In contrast to normal mice, theCREM-deficient mice show equal locomotor activity during the circadian cycle. The anatomy of the hypothalamic suprachiasmatic nuclei, the center of the endogenous pacemaker, is normal in mutant mice. Remarkably, CREM mutant mice also elicit a different emotional state, revealed by a lower anxiety in two different behavioral models, but they preserve the conditioned reactiveness to stress. These results demonstrate the high degree of functional specificity of each cAMP-responsive transcription factor in behavioral control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:34:33