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Titolo:
IN-SITU EVIDENCE OF NEOPLASTIC CELL PHAGOCYTOSIS BY MACROPHAGES IN PAPILLARY THYROID-CANCER
Autore:
FIUMARA A; BELFIORE A; RUSSO G; SALOMONE E; SANTONOCITO GM; IPPOLITO O; VIGNERI R; GANGEMI P;
Indirizzi:
UNIV CATANIA,IST MED INTERNA & MALATTIE ENDOCRINE & METAB,CATTEDRA ENDOCRINOL I-95123 CATANIA ITALY UNIV CATANIA,IST MED INTERNA & MALATTIE ENDOCRINE & METAB,CATTEDRA ENDOCRINOL I-95123 CATANIA ITALY UNIV CATANIA,PRESIDIO OSPED VITTORIO EMANUELE II,SERV ANAT & ISTOL PATOL I-95123 CATANIA ITALY UNIV CATANIA,CATTEDRA CHIRURG I-95123 CATANIA ITALY
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 5, volume: 82, anno: 1997,
pagine: 1615 - 1620
SICI:
0021-972X(1997)82:5<1615:IEONCP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA CLASS-II; GIANT-CELLS; LYMPHOCYTIC INFILTRATION; CARCINOMA; ASSOCIATION; EXPRESSION; MOLECULE; TUMORS; GLAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Fiumara et al., "IN-SITU EVIDENCE OF NEOPLASTIC CELL PHAGOCYTOSIS BY MACROPHAGES IN PAPILLARY THYROID-CANCER", The Journal of clinical endocrinology and metabolism, 82(5), 1997, pp. 1615-1620

Abstract

We evaluated the occurrence, tissue distribution, and prognostic Value of tumor-associated macrophages in 121 papillary thyroid carcinomas using immunohistochemical staining with anti-CD68 antibody in archivalparaffin-embedded sections. Lymphocytic infiltration and dendritic cell presence were also evaluated. Three groups were identified according to the presence and characteristics of macrophages: 1) tumors without evidence of infiltrating macrophages: (n = 35); 2) tumors with infiltrating macrophages but no evidence of neoplastic cells phagocytosis (n = 68); and 3) tumors with infiltrating macrophages and in situ evidence of active neoplastic cell phagocytosis (n = 18). Neoplastic cell phagocytosis by macrophages was positively correlated with both lymphocytic infiltration and dendritic cells (P = 0.0000), whereas it was negatively correlated with vascular invasion (P = 0.0032). Distant metastases developed in none of the 18 tumors with neoplastic cell phagocytosis, but occurred in 15 of 103 of the remaining tumors (P = 0.0647) and were significantly and negatively associated with lymphocytic infiltration or dendritic cells. The present study indicates, therefore, that immune reaction, involving neoplastic cell phagocytosis by macrophages and lymphocytic infiltration, plays a role in the development of distant metastases in patients with papillary thyroid cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:42:02