Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic polymorphism of CYP2D6 in the Japanese population
Autore:
Chida, M; Yokoi, T; Kosaka, Y; Chiba, K; Nakamura, H; Ishizaki, T; Yokota, J; Kinoshita, M; Sato, K; Inaba, M; Aoki, Y; Gonzalez, FJ; Kamataki, T;
Indirizzi:
Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Drug Metab, Div Pharmacobiodynam,Kita Ku, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan Chiba Univ, Dept Pharmaceut Sci, Chiba, Japan Chiba Univ Chiba JapanChiba Univ, Dept Pharmaceut Sci, Chiba, Japan Int Med Ctr Japan, Res Inst, Dept Clin Pharmacol, Tokyo, Japan Int Med CtrJapan Tokyo Japan s Inst, Dept Clin Pharmacol, Tokyo, Japan Kumamoto Univ, Dept Pharmaceut Sci, Kumamoto, Japan Kumamoto Univ Kumamoto Japan Univ, Dept Pharmaceut Sci, Kumamoto, Japan Natl Canc Ctr, Res Inst, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104Natl Canc Ctr, Res Inst, Tokyo 104, Japan Otsuka Pharmaceut Co Ltd, Tokushima 77101, Japan Otsuka Pharmaceut Co LtdTokushima Japan 77101 d, Tokushima 77101, Japan Gunma Univ, Sch Med, Dept Internal Med, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 ernal Med, Maebashi, Gumma 371, Japan Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Tokyo 170, Japan Japanese Fdn Canc Res Tokyo Japan 170 anc Chemotherapy, Tokyo 170, Japan Iwate Med Univ Sch, Dept Forens Med, Morioka, Iwate, Japan Iwate Med Univ Sch Morioka Iwate Japan Forens Med, Morioka, Iwate, Japan NCI, Mol Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PHARMACOGENETICS
fascicolo: 5, volume: 9, anno: 1999,
pagine: 601 - 605
SICI:
0960-314X(199910)9:5<601:GPOCIT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZER PHENOTYPE; OXIDATIVE DRUG-METABOLISM; CYTOCHROME-P450 CYP2D6; PARKINSONS-DISEASE; SPARTEINE METABOLISM; CHINESE SUBJECTS; LOWER PREVALENCE; DEBRISOQUINE; HYDROXYLATION; ALLELE;
Keywords:
CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*18; population study; cancer risk; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kamataki, T Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Drug Metab, Div Pharmacobiodynam,Kita Ku, N12W6, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ N12W6 Sapporo Hokkaido Japan 0600812 0812, Japan
Citazione:
M. Chida et al., "Genetic polymorphism of CYP2D6 in the Japanese population", PHARMACOGEN, 9(5), 1999, pp. 601-605

Abstract

The frequencies of CYP2D6 mutations in a Japanese population were investigated. Individuals were classified into three groups: control individuals, cancer patients and Parkinsonians, Genotyping for CYP2D6*3, CYP2D6*4 and CYP2D6*18 was carried out using the polymerase chain reaction, and that for CYP2D6*5 was also carried out using XbaI restriction fragment length polymorphism. The frequencies of the CYP2D6*3, CYP2D6*4, CYP2D6*5 and CYP2D6*18 mutant alleles were 0%, 0.77%, 4.10% and 0.53% in more than 256 Japanese control individuals, respectively. Based on these data, the population frequencyof the CYP2D6 poor metabolizer phenotype was estimated to be 0.29%. The distribution of the four mutated alleles was not significantly different between control individuals and cancer patients or Parkinsonians. Pharmacogenetics 9:601-605 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:58:34