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Titolo:
Biochemical markers of cognition: a proton MR spectroscopy study of normalhuman brain
Autore:
Jung, RE; Yeo, RA; Chiulli, SJ; Sibbitt, WL; Weers, DC; Hart, BL; Brooks, WM;
Indirizzi:
Univ New Mexico, Hlth Sci Ctr, Clin & Magnet Resonance Res Ctr, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 s Ctr, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Rheumatol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 matol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Radiol, Albuquerque, NM 87131 USA UnivNew Mexico Albuquerque NM USA 87131 adiol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Neurosci, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA St Josephs Rehabil Hosp, Albuquerque, NM USA St Josephs Rehabil Hosp Albuquerque NM USA bil Hosp, Albuquerque, NM USA
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 10, anno: 1999,
pagine: 3327 - 3331
SICI:
0959-4965(19991108)10:16<3327:BMOCAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; FRONTAL-LOBE; IN-VIVO; SPECTRA;
Keywords:
neuropsychological; processing speed; proton magnetic resonance spectroscopy; N-acetylaspartate; normal brain; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, WM Univ New Mexico, Hlth Sci Ctr, Clin & Magnet Resonance Res Ctr,1201 Yale Blvd NE, Albuquerque, NM 87131 USA Univ New Mexico 1201 Yale Blvd NE Albuquerque NM USA 87131 USA
Citazione:
R.E. Jung et al., "Biochemical markers of cognition: a proton MR spectroscopy study of normalhuman brain", NEUROREPORT, 10(16), 1999, pp. 3327-3331

Abstract

IN the current study we explored the relationship between neurometabolitesmeasured by proton magnetic resonance spectroscopy (H-1-MRS) and cognitiveability assessed with a battery of neuropsychological tests. Forty-five participants were;recruited from the local college community, and examined utilizing neuropsychological testing and H-1-MRS. Our central finding was that N-acetylaspartate (NAA) was associated with overall neuropsychological performance (F(1,42) = 23.16, p < 0.0001], r(2) = 0.35. We found an even stronger association between timed neuropsychological measures and NAA (F(1,42)= 31.15, p < 0.0001], r(2) = 0.43. These results reveal the specific relationship of NAA to neuropsychological functioning in:normal human brain. Thecurrent observations in healthy individuals are consistent with the hypothesis that variability in NAA levels and neuropsychological performance may be related to mitochondrial function. NeuroReport 10:3327-3331 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:09:32