Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Identification and distribution of Parkin in rat brain
Autore:
Horowitz, JM; Myers, J; Stachowiak, MK; Torres, G;
Indirizzi:
SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 Neurosci Program, Buffalo, NY 14214 USA SUNY Buffalo, Mol & Struct Neurobiol & Gene Therapy Program, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 Therapy Program, Buffalo, NY 14214 USA SUNY Buffalo, Dept Anat & Cell Biol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 Anat & Cell Biol, Buffalo, NY 14214 USA Medaille Coll, Buffalo, NY 14214 USA Medaille Coll Buffalo NY USA 14214Medaille Coll, Buffalo, NY 14214 USA
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 10, anno: 1999,
pagine: 3393 - 3397
SICI:
0959-4965(19991108)10:16<3393:IADOPI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; GENE; MUTATIONS; DELETIONS; DISEASE;
Keywords:
adrenals; cell degeneration; dopamine; immunoblotting; Parkinson's; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, G SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Pk Hall, Buffalo, NY 14214 USA SUNY Buffalo Pk Hall Buffalo NY USA 14214 Buffalo, NY 14214 USA
Citazione:
J.M. Horowitz et al., "Identification and distribution of Parkin in rat brain", NEUROREPORT, 10(16), 1999, pp. 3393-3397

Abstract

MUTATIONS within the amino acid sequence of Parkin, the encoded protein ofthe parkin gene, appear to trigger the degeneration of dopaminergic neurons in the substantia nigra. Here, the presence and anatomical distribution of Parkin within-the rat was examined. Immunoblot analysis of tissue homogenates showed two major bands at 50 and 44 kDa. Within the brain, Parkin-containing neurons were identified in the basal ganglia, including the substantia nigra and caudate-putamen. Parkin was visualized in the raphe nucleus, which as in the substantia nigra, was closely localized to monoaminergic-encoding neurons. In addition,Parkin was detected in laminar structures such as the cortex and hippocampus; a substantial number of Parkin-immunoreactiveneurons was seen in the cerebellum as well, Parkin therefore is widely distributed in brain pathways implicated in the pathology of Parkinson's. disease. NeuroReport port 10:3393-3397 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:21:04