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Titolo:
Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases
Autore:
Chung, YL; Williams, A; Ritchie, D; Williams, SCR; Changani, KK; Hope, J; Bell, JD;
Indirizzi:
Hammersmith Hosp, Robert Steiner Magnet Resonance Unit, MRC Clin Sci Ctr, Imperial Coll Sch Med, London W12 0HS, England Hammersmith Hosp London England W12 0HS Sch Med, London W12 0HS, England Inst Anim Hlth, BBSRC, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland Inst Anim Hlth Edinburgh Midlothian Scotland EH9 3JF Midlothian, Scotland Inst Anim Hlth, MRC, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland Inst Anim Hlth Edinburgh Midlothian Scotland EH9 3JF Midlothian, Scotland Inst Psychiat, Dept Clin Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF n Neurosci, London SE5 8AF, England Inst Anim Hlth, BBSRC, Compton Lab, Compton RG20 7NN, Berks, England Inst Anim Hlth Compton Berks England RG20 7NN on RG20 7NN, Berks, England
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 10, anno: 1999,
pagine: 3471 - 3477
SICI:
0959-4965(19991126)10:17<3471:CMSFGA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; BASAL GANGLIA; SCRAPIE; NMR; RELAXATION; INTENSITY; MATTER; CT;
Keywords:
CJD; histopathology; hamster; magnetic resonance imaging; scrapie;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, YL Hammersmith Hosp, Robert Steiner Magnet Resonance Unit, MRC ClinSci Ctr, Imperial Coll Sch Med, DuCane Rd, London W12 0HS, England Hammersmith Hosp DuCane Rd London England W12 0HS 0HS, England
Citazione:
Y.L. Chung et al., "Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases", NEUROREPORT, 10(17), 1999, pp. 3471-3477

Abstract

MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosiswere found to correlate with hypo-intense and hyper-intense changes in theconventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:32:18