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Titolo:
Effect of age and neuroleptics on tyrosine hydroxylase-IR in sector CA2 ofschizophrenic brain
Autore:
Benes, FM; Todtenkopf, MS;
Indirizzi:
McLean Hosp, Struct Neurosci Lab, Belmont, MA 02478 USA McLean Hosp Belmont MA USA 02478 ruct Neurosci Lab, Belmont, MA 02478 USA Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Neurosci Program, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 10, anno: 1999,
pagine: 3527 - 3530
SICI:
0959-4965(19991126)10:17<3527:EOAANO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC INNERVATION; RECEPTOR-BINDING; HIPPOCAMPAL-FORMATION; PREFRONTAL CORTEX; CINGULATE CORTEX; CEREBRAL-CORTEX; NEURONS; RAT; ANTIBODIES; NEOCORTEX;
Keywords:
antipsychotics; dopamine; neurodevelopment; onset of schizophrenia; sector CA2; trisynaptic pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Benes, FM McLean Hosp, Struct Neurosci Lab, 115 Mill St, Belmont, MA 02478USA McLean Hosp 115 Mill St Belmont MA USA 02478 lmont, MA 02478 USA
Citazione:
F.M. Benes e M.S. Todtenkopf, "Effect of age and neuroleptics on tyrosine hydroxylase-IR in sector CA2 ofschizophrenic brain", NEUROREPORT, 10(17), 1999, pp. 3527-3530

Abstract

THE density of TH-IR varicosities was analyzed in the hippocampus of 15 normal controls and 11 schizophrenics. The average density of varicosities inapposition with pyramidal cells and in the neuropil was 30-35% lower in CA2, but not other sectors of schizophrenics. Age was correlated with varicosity density in all sectors, particularly in CA2 where young patients showeda 50% reduction on non-pyramidal cells. Neuroleptic dose showed a negativecorrelation with the density of varicosities, and notably the dose of young schizophrenics was four times higher than that of older subjects. Thus, antipsychotic dose appears to be associated with a suppression of a normal age-related increase of dopamine projections to CA2 during the early phases of schizophrenia. (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 12/07/20 alle ore 01:15:28