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Titolo:
alpha-lipoic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity
Autore:
Aguirre, N; Barrionuevo, M; Ramirez, MJ; Del Rio, J; Lasheras, B;
Indirizzi:
Univ Navarra, Sch Med, Dept Pharmacol, Pamplona 31008, Spain Univ NavarraPamplona Spain 31008 Dept Pharmacol, Pamplona 31008, Spain
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 10, anno: 1999,
pagine: 3675 - 3680
SICI:
0959-4965(19991126)10:17<3675:AAP3(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; BODY-TEMPERATURE; REACTIVE GLIOSIS; MDMA ECSTASY; SEROTONIN; NEURODEGENERATION; TERMINALS; METHYLENEDIOXYMETHAMPHETAMINE; INVOLVEMENT;
Keywords:
5-HT (serotonin; 5-hydroxytryptamine); glial fibrillary acidic protein (GFAP); alpha-lipoic acid (thioctic acid); 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lasheras, B Univ Navarra, Sch Med, Dept Pharmacol, C Irunlarrea 1, Pamplona 31008, Spain Univ Navarra C Irunlarrea 1 Pamplona Spain 31008 31008, Spain
Citazione:
N. Aguirre et al., "alpha-lipoic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity", NEUROREPORT, 10(17), 1999, pp. 3675-3680

Abstract

A single administration of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-HT) content and [H-3]paroxetine-labeled 5-HT transporter density in the frontal cortex, striatum and hippocampus by 40-60% 1 week later, MDMA treatment also increased glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus. Repeated administration of the metabolic antioxidant alpha-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changesin the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:10:10