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Titolo:
Glutamate receptors differ in rod- and cone-dominated off-center bipolar cells
Autore:
Maple, BR; Gao, F; Wu, SM;
Indirizzi:
Baylor Coll Med, Cullen Eye Inst, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 llen Eye Inst, Houston, TX 77030 USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 10, anno: 1999,
pagine: 3605 - 3610
SICI:
0959-4965(19991126)10:17<3605:GRDIRA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIGER SALAMANDER RETINA; AMPA RECEPTORS; GANGLION-CELLS; SUBUNIT COMPOSITION; KAINATE RECEPTORS; SYNAPTIC CURRENTS; ON-CENTER; NEURONS; INPUTS; DESENSITIZATION;
Keywords:
cyclothiazide; ionotropic glutamate receptors; noise analysis; power spectral density function; retinal bipolar cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Maple, BR Baylor Coll Med, Cullen Eye Inst, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 nst, Houston, TX 77030 USA
Citazione:
B.R. Maple et al., "Glutamate receptors differ in rod- and cone-dominated off-center bipolar cells", NEUROREPORT, 10(17), 1999, pp. 3605-3610

Abstract

THE axon morphology of off-center bipolar cells in salamander retinal slices was correlated with light responses and dendritic glutamate responses ofthese cells under voltage clamp. Cells with telodendria ramifying exclusively in the distal one-quarter of the inner plexiform layer were rod dominated, whereas cells with more centrally ramifying telodendria were cone dominated. The glutamate responses of the centrally ramifying cells displayed more apparent desensitization and a smaller underlying single channel conductance (1.2 +/- 0.3 pS) than did the distally ramifying cells (2.8 +/- 0.4 pS), although the responses for both classes of cells were strongly enhanced by cyclothiazide. These results suggest that different subtypes of AMPA receptors are present on rod- and cone-dominated cells, and that these may differ with respect to desensitization kinetics. (C), 1999 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:52:40