Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3
Autore:
Futatsugi, A; Kato, K; Ogura, H; Li, ST; Nagata, E; Kuwajima, G; Tanaka, K; Itohara, S; Mikoshiba, K;
Indirizzi:
Japan Sci & Technol Corp, Mikoshiba Calciosignal Net Project, Exploratory Res Adv Technol, Bunkyo Ku, Tokyo 1130021, Japan Japan Sci & Technol Corp Tokyo Japan 1130021 yo Ku, Tokyo 1130021, Japan Shionogi & Co Ltd, Shionogi Inst Med Sci, Settsu, Osaka 5660022, Japan Shionogi & Co Ltd Settsu Osaka Japan 5660022 Settsu, Osaka 5660022, Japan Univ Tokyo, Inst Med Sci, Dept Mol Neurobiol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 eurobiol, Minato Ku, Tokyo 1088639, Japan Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan Eisai & Co Ltd Tsukuba Ibaraki Japan 3002635 kuba, Ibaraki 3002635, Japan Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Neurol, Shinjuku Ku, Tokyo 1608582, Japan RIKEN, Brain Sci Inst, Lab Behav Genet, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 ehav Genet, Wako, Saitama 3510198, Japan RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 robiol Lab, Wako, Saitama 3510198, Japan
Titolo Testata:
NEURON
fascicolo: 3, volume: 24, anno: 1999,
pagine: 701 - 713
SICI:
0896-6273(199911)24:3<701:FONLAS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; RAT HIPPOCAMPAL SLICES; GYRUS IN-VITRO; SYNAPTIC PLASTICITY; SKELETAL-MUSCLE; DENTATE GYRUS; CA2+ RELEASE; AUTORADIOGRAPHIC ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, K Japan Sci & Technol Corp, Mikoshiba Calciosignal Net Project, Exploratory Res Adv Technol, Bunkyo Ku, 2-28-8 Honkomagome, Tokyo 1130021, Japan Japan Sci & Technol Corp 2-28-8 Honkomagome Tokyo Japan 1130021 n
Citazione:
A. Futatsugi et al., "Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3", NEURON, 24(3), 1999, pp. 701-713

Abstract

To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTPin wild-type mice, this LTP was not blocked by the NMDA receptor antagonist D-APS but was partially dependent on L-type voltage-dependent Ca2+ channels (VDCCs) and metabotropic glutamate receptors (mGluRs). Long-term depression (LTD) was not induced in RyR3-deficient mice. RyR3-deficient mice also exhibited improved spatial learning on a Morris water maze task. These results suggest that in wild-type mice, in contrast to the excitatory role of Ca2+ influx, RyR3-mediated intracellular Ca2+ ([Ca2+]) release from endoplasmic reticulum (ER) may inhibit hippocampal LTP and spatial learning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:35:11