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Titolo: Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: Relation to stroke etiology
Autore: Zunker, P; Schick, A; Padro, T; Kienast, J; Phillips, A; Ringelstein, EB;
- Indirizzi:
- Univ Kiel Hosp, Dept Neurol, D-24105 Kiel, Germany Univ Kiel Hosp Kiel Germany D-24105 , Dept Neurol, D-24105 Kiel, Germany Univ Munster Hosp, Dept Neurol, Munster, Germany Univ Munster Hosp Munster Germany r Hosp, Dept Neurol, Munster, Germany Univ Munster Hosp, Dept Med, Munster, Germany Univ Munster Hosp Munster Germany ster Hosp, Dept Med, Munster, Germany
- Titolo Testata:
- NEUROLOGICAL RESEARCH
fascicolo: 8,
volume: 21,
anno: 1999,
pagine: 727 - 732
- SICI:
- 0161-6412(199912)21:8<727:TPAAPA>2.0.ZU;2-H
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- MOLECULAR-WEIGHT HEPARIN; CORONARY-ARTERY DISEASE; NONVALVULAR ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; HEMOSTATIC FUNCTION; STANDARD HEPARIN; RAPID INHIBITOR; ANGINA-PECTORIS; T-PA;
- Keywords:
- tissue-type plasminogen activator; plasminogen activator inhibitor-1; ischemic stroke; large artery atherosclerosis; small vessel occlusion; cardioembolism;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 38
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Zunker, P Univ Kiel Hosp, Dept Neurol, Niemannsweg 147, D-24105 Kiel, Germany Univ Kiel Hosp Niemannsweg 147 Kiel Germany D-24105 el, Germany
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- Citazione:
- P. Zunker et al., "Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: Relation to stroke etiology", NEUROL RES, 21(8), 1999, pp. 727-732
Abstract
Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events suchas stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1 antigen and activity, as well as tPA/PAI-1 complex in patients with acute stroke. Stroke subtypes were classified according to the TOAST criteria. From 132 consecutively screened patients, 89 (100%) were enrolled in this study, including 42 patients (47%) with large artery atherosclerosis (LAA), 32 (36%) with small vessel occlusion (SVO), and 15 (17%) with cardioembolism (CE). Nineteen age-matched neurologic patients without manifestations of cerebrovascular disease served as control subjects (CS). Patients with acute stroke had significantly higher plasma levels of tPA antigen (p < 0.001), PAI-1 antigen (p < 0.05) and PAI activity (p < 0.05) than patients in the control group, t-PA antigen, PAI activity and tPA/PAI-1 complex levels were similar regardless of stroke etiology. Only PAI-1 antigen was lower in patients with cardioembolic stroke than in stroke patients with LAA (p < 0.05). Plasma tPA antigen, PAI-1 antigen, and PAI activity aresignificantly increased in patients with acute ischemic stroke. Except forPAI-1 antigen, this increase appears not to be related to the underlying stroke etiology.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:50:21