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Titolo:
Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: Relation to stroke etiology
Autore:
Zunker, P; Schick, A; Padro, T; Kienast, J; Phillips, A; Ringelstein, EB;
Indirizzi:
Univ Kiel Hosp, Dept Neurol, D-24105 Kiel, Germany Univ Kiel Hosp Kiel Germany D-24105 , Dept Neurol, D-24105 Kiel, Germany Univ Munster Hosp, Dept Neurol, Munster, Germany Univ Munster Hosp Munster Germany r Hosp, Dept Neurol, Munster, Germany Univ Munster Hosp, Dept Med, Munster, Germany Univ Munster Hosp Munster Germany ster Hosp, Dept Med, Munster, Germany
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 8, volume: 21, anno: 1999,
pagine: 727 - 732
SICI:
0161-6412(199912)21:8<727:TPAAPA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT HEPARIN; CORONARY-ARTERY DISEASE; NONVALVULAR ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; HEMOSTATIC FUNCTION; STANDARD HEPARIN; RAPID INHIBITOR; ANGINA-PECTORIS; T-PA;
Keywords:
tissue-type plasminogen activator; plasminogen activator inhibitor-1; ischemic stroke; large artery atherosclerosis; small vessel occlusion; cardioembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Zunker, P Univ Kiel Hosp, Dept Neurol, Niemannsweg 147, D-24105 Kiel, Germany Univ Kiel Hosp Niemannsweg 147 Kiel Germany D-24105 el, Germany
Citazione:
P. Zunker et al., "Tissue plasminogen activator and plasminogen activator inhibitor in patients with acute ischemic stroke: Relation to stroke etiology", NEUROL RES, 21(8), 1999, pp. 727-732

Abstract

Recent studies suggest that high plasma levels of tissue-type plasminogen activator (tPA) and its inhibitor (plasminogen activator inhibitor-1, PAI-1) are markers of an increased risk of atherothrombotic ischemic events suchas stroke and myocardial infarction. In this prospective study, we measured tPA antigen, PAI-1 antigen and activity, as well as tPA/PAI-1 complex in patients with acute stroke. Stroke subtypes were classified according to the TOAST criteria. From 132 consecutively screened patients, 89 (100%) were enrolled in this study, including 42 patients (47%) with large artery atherosclerosis (LAA), 32 (36%) with small vessel occlusion (SVO), and 15 (17%) with cardioembolism (CE). Nineteen age-matched neurologic patients without manifestations of cerebrovascular disease served as control subjects (CS). Patients with acute stroke had significantly higher plasma levels of tPA antigen (p < 0.001), PAI-1 antigen (p < 0.05) and PAI activity (p < 0.05) than patients in the control group, t-PA antigen, PAI activity and tPA/PAI-1 complex levels were similar regardless of stroke etiology. Only PAI-1 antigen was lower in patients with cardioembolic stroke than in stroke patients with LAA (p < 0.05). Plasma tPA antigen, PAI-1 antigen, and PAI activity aresignificantly increased in patients with acute ischemic stroke. Except forPAI-1 antigen, this increase appears not to be related to the underlying stroke etiology.

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Documento generato il 20/01/21 alle ore 12:50:21