Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Candida albicans clinical isolates inactivated by formalin with different adherence to buccal epithelial cells induce proinflammatory and regulatory cytokines in human peripheral blood mononuclear cells
Autore:
Kunze, R; Schutz, B; Schrodl, W; Bernhardt, H;
Indirizzi:
Univ Greifswald, Dept Clin Microbiol, Clin Internal Med, Greifswald, Germany Univ Greifswald Greifswald Germany in Internal Med, Greifswald, Germany Inst Microecol, Herborn Horbach, Germany Inst Microecol Herborn Horbach Germany roecol, Herborn Horbach, Germany Imtox Inc, Inst Immunbiol Res, Berlin, Germany Imtox Inc Berlin GermanyImtox Inc, Inst Immunbiol Res, Berlin, Germany
Titolo Testata:
MYCOSES
fascicolo: 9-10, volume: 42, anno: 1999,
pagine: 529 - 538
SICI:
0933-7407(199911)42:9-10<529:CACIIB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE;
Keywords:
Candida albicans; cytokines; peripheral blood mononuclear cells; adherence; immune system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Bernhardt, H Clin Innere Med A, F Loeffler Str 23A, D-17489 Greifswald, Germany Clin Innere Med A F Loeffler Str 23A Greifswald Germany D-17489
Citazione:
R. Kunze et al., "Candida albicans clinical isolates inactivated by formalin with different adherence to buccal epithelial cells induce proinflammatory and regulatory cytokines in human peripheral blood mononuclear cells", MYCOSES, 42(9-10), 1999, pp. 529-538

Abstract

Besides the activation of phagocytes, the release of cytokines is the mostimportant immunological defence mechanism of an organism against infectionwith Candida albicans, On the other hand cytokines induced in the organismby the yeast itself are able to modulate the immune responses of the host. We investigated whether eight clinically isolated strains of C. albicans inactivated by formalin as well as a laboratory strain were able to induce proinflammatory and regulatory cytokines in peripheral blood mononuclear cells (PBMC) of four different donors. Under our assay conditions the yeast strains induced the cytokines interleukin-1 beta (IL-1 beta), interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) in PBMC to varying extents, but not the cytokine interleukin-4 (IL-4). We observed a difference in the reaction of the individual donors to the stimulus C. albicans but on the other hand the extent of the cytokine signal seemed to be dependent on the yeast strain as well, No correlation was found between the ability of the individual C, albicans strains to induce cytokines in PBMC and their ability to adhere to buccal epithelial cells. Determination of the cytokine induction potential of C. albicans strains possibly may contribute to the detection of new virulence factors of this yeast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:14:30