Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The DRD2 Taql polymorphism and symptoms of attention deficit hyperactivitydisorder
Autore:
Rowe, DC; Van den Oord, EJCG; Stever, C; Giedinghagen, LN; Gard, JMC; Cleveland, HH; Gilson, M; Terris, ST; Mohr, JH; Sherman, S; Abramowitz, A; Waldman, ID;
Indirizzi:
Univ Arizona, Grad Program Genet, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 Grad Program Genet, Tucson, AZ 85721 USA Univ Arizona, Div Family Studies, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 Div Family Studies, Tucson, AZ 85721 USA Univ Utrecht, Fac Sociale Wetenschappen, Vakgrp Pedagogiek, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands Univ Arizona, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721Univ Arizona, Tucson, AZ 85721 USA Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA30322 Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ, Dept Genet & Mol Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 pt Genet & Mol Med, Atlanta, GA 30322 USA Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 niv, Dept Psychiat, Atlanta, GA 30322 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 4, anno: 1999,
pagine: 580 - 586
SICI:
1359-4184(199911)4:6<580:TDTPAS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE; LINKAGE DISEQUILIBRIUM; DOPAMINE TRANSPORTER; AL ALLELE; A1 ALLELE; ASSOCIATION; ALCOHOLISM; LOCUS;
Keywords:
DRD2; dopamine receptor 2; attention deficit; hyperactivity disorder (ADHD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rowe, DC Univ Arizona, Grad Program Genet, Campus Box 210033, Tucson, AZ 85721 USA Univ Arizona Campus Box 210033 Tucson AZ USA 85721 , AZ 85721 USA
Citazione:
D.C. Rowe et al., "The DRD2 Taql polymorphism and symptoms of attention deficit hyperactivitydisorder", MOL PSYCHI, 4(6), 1999, pp. 580-586

Abstract

The relationship of the DRD2 Taql-A1 allele to hyperactive/impulsive and inattentive symptoms of attention deficit hyperactivity disorder (ADHD) in children and adolescents was examined in a sample of clinic-referred children and their siblings, and control children and their siblings (n = 236). The contribution of genetic dominance and additivity to mean differences among the A2A2, A1A2, and A1A1 genotypes was estimated using structural equation modeling. The effect of genetic additivity was statistically significant for both traits in an analysis of all children. The heritability from the DRD2 locus was estimated at 4.27% for hyperactive-impulsive symptoms and 2.12% for inattentive symptoms. Children with the A2A2 genotype had the highest mean level of symptoms. To control for any possible effects of populationstratification, this analysis was repeated with parental genotypes as controls. In this smaller sample, although the direction of the effect was the same as that in the whole sample, the genotypic differences failed to reachconventional significance levels and the effect sizes were smaller (h(2) =1.62% and 0.79%, respectively). Furthermore, a genotype relative risk testof children who had questionnaire-based diagnoses of ADHD also failed to yield evidence of either association or linkage. Given that the Al allele was expected to be the high risk allele, and that results were non-significant in tests that controlled for population heterogeneity, we doubt that thisDRD2 polymorphism influences symptoms of ADHD in childhood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:40:07