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Titolo:
Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism
Autore:
Ueno, S; Nakamura, M; Mikami, M; Kondoh, K; Ishiguro, H; Arinami, T; Komiyama, T; Mitsushio, H; Sano, A; Tanabe, H;
Indirizzi:
Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaragi 3058575, Japan Univ Tsukuba Tsukuba Ibaragi Japan 3058575 sukuba, Ibaragi 3058575, Japan NCNP, Natl Hosp Mental Nervous & Muscular Disorders, Tokyo 1878551, Japan NCNP Tokyo Japan 1878551 vous & Muscular Disorders, Tokyo 1878551, Japan
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 4, anno: 1999,
pagine: 552 - 557
SICI:
1359-4184(199911)4:6<552:IOANPO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 RECEPTOR GENE; SCHIZOPHRENIA; RELATIVES; DISORDERS; LINKAGE; ALLELE; DRD2;
Keywords:
human dopamine transporter (DAT1); polymorphism; alcoholism; schizophrenia; association study; 5p15.3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sano, A Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295,Japan Ehime Univ Shigenobu Ehime Japan 7910295 bu, Ehime 7910295, Japan
Citazione:
S. Ueno et al., "Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism", MOL PSYCHI, 4(6), 1999, pp. 552-557

Abstract

Human dopamine transporter gene (DAT1) has a variable number of tandem repeats (VNTR) in its 3'-untranslated region (UTR). The association between the VNTR polymorphism and neuropsychiatric disorders has been studied, but their relationship is still unclear. Here we identified a novel polymorphism in the 3'-UTR of the DAT1 gene, G2319A, and a significant association between the polymorphism and alcoholism was observed in both genotypic and allelic frequencies (P = 0.040 and 0.019, extended Fisher's exact test, respectively). There was a significant gene dose effect on the risk for alcoholism associated with the 2319-A allele (chi(2) = 6.16, df = 2, P = 0.046, linearity tendency test: Cochranq-Armitage analysis). Moreover, in the haplotype analysis with G2319A- and VNTR-polymorphisms, a positive gene dose efffect on the risk with the A10 allele (P = 0.044, linearity tendency test) and a negative gene dose effect with the G10 allele (P = 0.010 , linearity tendency test) for alcoholism were significantly detected. Odds ratio for alcoholism with the A10 and G10 alleles were 1.76 (1.12-2.76) and 0.53 (0.32-0.79), respectively. These results indicate that the DAT1 gene may confer vulnerability to alcoholism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:36:09