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Titolo:
Neurobiological basis of relapse prediction in stimulant-induced psychosisand schizophrenia: the role of sensitization
Autore:
Yui, K; Goto, K; Ikemoto, S; Ishiguro, T; Angrist, B; Duncan, GE; Sheitman, BB; Lieberman, JA; Bracha, SH; Ali, SF;
Indirizzi:
US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Neurochem Lab, Jefferson, AR 72079 USA US FDA Jefferson AR USA 72079 col, Neurochem Lab, Jefferson, AR 72079 USA Jichi Med Sch, Dept Psychiat, Minami Kawachi, Tochigi 3290498, Japan JichiMed Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan Jichi Med Sch, Dept Legal Med & Human Genet, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan NYU, Sch Med, Psychiat Serv, Vet Adm Med Ctr, New York, NY 10010 USA NYU New York NY USA 10010 t Serv, Vet Adm Med Ctr, New York, NY 10010 USA Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA PTSD, VA Pacific Ctr, Honolulu, HI USA PTSD Honolulu HI USAPTSD, VA Pacific Ctr, Honolulu, HI USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 4, anno: 1999,
pagine: 512 - 523
SICI:
1359-4184(199911)4:6<512:NBORPI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-INDUCED BEHAVIORS; MEDIAL PREFRONTAL CORTEX; COCAINE-INDUCED PARANOIA; DOPAMINE RELEASE; INDUCED ROTATION; METHAMPHETAMINE PSYCHOSIS; SPONTANEOUS RECURRENCE; AMPHETAMINE PSYCHOSIS; STRESS; RATS;
Keywords:
sensitization; stimulant; methamphetamine psychosis; spontaneous recurrence; stress; cocaine psychosis; noradrenaline; dopamine; schizophrenia; phencyclidine; rotational behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Ali, SF US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Neurochem Lab, Jefferson, AR 72079 USA US FDA Jefferson AR USA 72079 rochem Lab, Jefferson, AR 72079 USA
Citazione:
K. Yui et al., "Neurobiological basis of relapse prediction in stimulant-induced psychosisand schizophrenia: the role of sensitization", MOL PSYCHI, 4(6), 1999, pp. 512-523

Abstract

A number of consistent clinical observations provide direction for the hypothesis that pathological sensitization of neuronal systems may be an important factor for relapse or the onset of stimulant-induced psychosis leg, methamphetamine or amphetamine psychosis, cocaine psychosis and phencyclidinepsychosis and schizophrenia. First, psychotic symptoms can be produced in normal subjects by stimulants. Secondly, a targe portion of schizophrenic patients exhibit exacerbation of psychotic symptoms in response to stimulants at doses which would not be psychotogenic in normal subjects. Lastly, theability of stress to precipitate the onset and relapse of schizophrenia iswell documented. In this regard, acute responses to stimulants provide useful information for relapse prediction of schizophrenia and substance abuse. This paper addresses the nature and role of pathological sensitization inrelapse of stimulant- and phencyclidine-induced psychosis and schizophrenia, and its relation to pathophysiology of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:08:31