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Titolo:
Immunomodulating properties of MDMA alone and in combination with alcohol:A pilot study
Autore:
Pacifici, R; Zuccaro, P; Farre, M; Pichini, S; Di Carlo, S; Roset, PN; Ortuno, J; Segura, J; de la Torre, R;
Indirizzi:
Univ Autonoma Barcelona, Dept Pharmacol, Inst Municipal Invest Med, E-08003 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08003 E-08003 Barcelona, Spain Ist Super Sanita, Dept Clin Biochem, I-00161 Rome, Italy Ist Super SanitaRome Italy I-00161 pt Clin Biochem, I-00161 Rome, Italy Univ Pompeu Fabra, Barcelona, Spain Univ Pompeu Fabra Barcelona SpainUniv Pompeu Fabra, Barcelona, Spain
Titolo Testata:
LIFE SCIENCES
fascicolo: 26, volume: 65, anno: 1999,
pagine: PL309 - PL316
SICI:
0024-3205(19991119)65:26<PL309:IPOMAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; IMMUNE FUNCTION; STRESS;
Keywords:
MDMA; humans; immunity; alcohol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: de la Torre, R Univ Autonoma Barcelona, Dept Pharmacol, Inst Municipal Invest Med, DoctorAiguader 80, E-08003 Barcelona, Spain Univ Autonoma Barcelona Doctor Aiguader 80 Barcelona Spain E-08003
Citazione:
R. Pacifici et al., "Immunomodulating properties of MDMA alone and in combination with alcohol:A pilot study", LIFE SCI, 65(26), 1999, pp. PL309-PL316

Abstract

Cell-mediated immune response after the administration of MDMA alone and in combination with alcohol was evaluated in a randomized, double-blind, double-dummy, cross-over pilot clinical trial conducted in four healthy MDMA consumers who received single oral doses of 75 mg MDMA (n = 2) or 100 mg MDMA (n = 2), alcohol (0.8 mg/kg), MDMA and alcohol, or placebo. Acute MDMA treatment produced a time-dependent immune dysfunction associated with MDMA plasma concentrations. Although total leukocyte count remained unchanged, there was a decrease in the CD4 T/CD8 T-cell ratio as well as in the percentage of mature T lymphocytes, probably because of a decrease in both the percentage and absolute number of T helper cells. The decrease in CD4 T-cell counts and in the functional responsiveness of lymphocytes to mitogenic stimulation was dose-dependent. The correlation between MDMA pharmacokinetics and the profile of MDMA-induced immune dysfunction suggests that alteration of the immune system may be mediated by the central nervous system. Alcohol consumption produced a decrease in T helper cells, B lymphocytes, and PHA-induced lymphocyte proliferation. Combined MDMA and alcohol produced the greatest suppressive effect on CD4 T-cell count and PHA-stimulated lymphoproliferation. Immune function was partially restored at 24 hours. These resultsprovide the first evidence that recreational use of MDMA alone or in combination with alcohol alters the immunological status. (C) 1999 Elsevier Science Inc.

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Documento generato il 06/04/20 alle ore 08:46:40