Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic reduction in renal mass in the rat attenuates ischemia/reperfusioninjury and does not impair tubular regeneration
Autore:
Vercauteren, SR; Ysebaert, DK; De Greef, KE; Eyskens, EJ; De Broe, ME;
Indirizzi:
Univ Antwerp Hosp, Dept Nephrol Hypertens, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 ypertens, B-2650 Edegem, Belgium Univ Antwerp Hosp, Dept Expt Surg, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 xpt Surg, B-2650 Edegem, Belgium
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 12, volume: 10, anno: 1999,
pagine: 2551 - 2561
SICI:
1046-6673(199912)10:12<2551:CRIRMI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; PROXIMAL TUBULES; REMNANT KIDNEY; NITRIC-OXIDE; FAILURE; MODEL; PROTECTS; NEPHROPATHY; FIBROSIS; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: De Broe, ME Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 Belgium
Citazione:
S.R. Vercauteren et al., "Chronic reduction in renal mass in the rat attenuates ischemia/reperfusioninjury and does not impair tubular regeneration", J AM S NEPH, 10(12), 1999, pp. 2551-2561

Abstract

It is not known whether a kidney with chronic structural and functional changes is more vulnerable to an acute renal insult, and whether its regeneration capacity after injury is altered. To study this question, Lewis rats were submitted 10 wk after 5/6 nephrectomy to an ischemic insult of 60 min (remnant kidney [RK] group). Functional and morphologic data of the RK groupwere compared with data obtained in IO-wk uninephrectomized (1K) and normal (2K) Lewis rats with unilateral and bilateral renal ischemia, respectively. The acute postischemic decrease in creatinine clearance was smallest in the RK group, followed by the 2K and 1K groups, respectively. At days 1 and3, fewer proximal tubules in the outer stripe of the outer medulla of the RK and 2K groups had undergone acute tubular necrosis compared with the 1K group. The mean percentage of tubules with signs of regeneration was maximal at day 3 in the three experimental groups. At day 10, regeneration was almost complete in the three groups. The number of leukocytes (OX1(+) cells) present in the RK before ischemia did not increase after ischemia/reperfusion injury (377 +/- 146 cells/mm(2) at day 0) in contrast to the 1K and 2K groups. In the latter groups, the number of leukocytes had increased gradually, reaching a maximum at day 15 (1K: 960 +/- 308 cells/mm(2)) and day 10 (2K: 668 +/- 164 cells/mm(2)), respectively. In conclusion, this study has shown that an RK exhibiting chronic morphologic changes of interstitial fibrosis and tubular atrophy is protected against ischemia/reperfusion injury, and that its regeneration capacity is preserved. The reperfusion injury is not followed by further accumulation of leukocytes, which were already present in the RK before ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:42:54