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Titolo:
An inhibitory interface gates impulse traffic between the input and outputstations of the amygdala
Autore:
Royer, S; Martina, M; Pare, D;
Indirizzi:
Univ Laval, Fac Med, Dept Physiol, Neurophysiol Lab, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 Quebec City, PQ G1K 7P4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 23, volume: 19, anno: 1999,
pagine: 10575 - 10583
SICI:
0270-6474(199912)19:23<10575:AIIGIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-LIKE IMMUNOREACTIVITY; CENTRAL NUCLEUS; INTRINSIC CONNECTIONS; LATERAL NUCLEUS; BASAL NUCLEUS; BRAIN-STEM; PHA-L; PROJECTIONS; RAT; COMPLEX;
Keywords:
amygdala; intra-amygdaloid pathways; intercalated cell masses; central amygdaloid nucleus; feedforward inhibition; fear conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pare, D Univ Laval, Fac Med, Dept Physiol, Neurophysiol Lab, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 City, PQ G1K 7P4, Canada
Citazione:
S. Royer et al., "An inhibitory interface gates impulse traffic between the input and outputstations of the amygdala", J NEUROSC, 19(23), 1999, pp. 10575-10583

Abstract

The central amygdaloid nucleus projects to brainstem and hypothalamic nuclei mediating fear responses and receives convergent sensory inputs from thebasolateral amygdaloid complex. However, interposed between the basolateral complex and central nucleus is a string of interconnected GABAergic cell clusters, the intercalated cell masses. Here, we analyzed how intercalated neurons influence impulse traffic between the basolateral complex and central nucleus using whole-cell recordings, microstimulation, and local application of glutamate receptor antagonists in brain slices. Our results suggestthat intercalated neurons receive glutamatergic inputs from the basolateral complex and generate feedforward inhibition in neurons of the central nucleus. As the position of the recording site was shifted medially, intercalated cells projected to gradually more medial sectors of the central nucleusand were maximally responsive to progressively more medial stimulation sites in the basolateral complex. Thus, there is a latero-medial correspondence between the position of intercalated cells, their projection site in the central nucleus, and the source of their excitatory afferents in the basolateral complex. In addition, basolateral stimulation sites eliciting maximalexcitatory responses in intercalated neurons were flanked laterally by sites eliciting prevalently inhibitory responses via the activation of intercalated cells located more laterally. As a result, the feedforward inhibitiongenerated by intercalated neurons and, indirectly, the amplitude of the responses of central neurons could be increased or decreased depending on which combination of amygdala nuclei are activated and in what sequence. Thus,the output of the central nucleus depends not only on the nature and intensity of sensory inputs but also on their timing and origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:07:27