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Titolo:
LONG-TERM POTENTIATION AND LONG-TERM DEPRESSION ARE INDUCED THROUGH PHARMACOLOGICALLY DISTINCT NMDA RECEPTORS
Autore:
HRABETOVA S; SACKTOR TC;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PHARMACOL,LAB MOL NEUROSCI,BOX 29,150 CLARKSONAVE BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT PHARMACOL,LAB MOL NEUROSCI BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT NEUROL BROOKLYN NY 11203
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 226, anno: 1997,
pagine: 107 - 110
SICI:
0304-3940(1997)226:2<107:LPALDA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-FREQUENCY STIMULATION; AREA CA1; HIPPOCAMPUS; ACTIVATION; LTP; DEPOTENTIATION;
Keywords:
LONG-TERM POTENTIATION; LONG-TERM DEPRESSION; DEPOTENTIATION; -((RS)-2-CARBOXYPIPERAZIN-4-YL)PROPYL-1-PHOSPHONIC ACID (CPP); NR2D SUBUNIT; EPSILON-4 SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Hrabetova e T.C. Sacktor, "LONG-TERM POTENTIATION AND LONG-TERM DEPRESSION ARE INDUCED THROUGH PHARMACOLOGICALLY DISTINCT NMDA RECEPTORS", Neuroscience letters, 226(2), 1997, pp. 107-110

Abstract

N-Methyl-D-aspartate (NMDA) receptor activation initiates both homosynaptic long-term depression (LTD) and long-term potentiation (LTP) in the CA1 region of the hippocampus. The mechanism by which two opposingforms of synaptic plasticity can be initiated through the activation of a single receptor is not known. We examined the effects of two competitive antagonists on the induction of LTP and LTD, D-2-amino-5-phosphonovaleric acid (D-APS), a broad spectrum inhibitor of the NMDA receptor, and -((RS)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), an antagonist that binds with high affinity to conventional NMDA receptors subtypes, but not to atypical subtypes that are relatively independent of voltage-dependent Mg2+-blockade. As has previously been reported, LTP, LTD, and depotentiation were all blocked by applications of D-APS. In contrast, only LTP, but not LTD or depotentiation, was blocked by CPP. These observations suggest that decreases and increases of synaptic strength are mediated by the activation of distinct NMDA receptor subpopulations. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:56:21