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Titolo:
Systemic doxycycline administration in the treatment of periodontal infections - (I) - Effect on the subgingival microbiota
Autore:
Feres, M; Haffajee, AD; Goncalves, C; Allard, KA; Som, S; Smith, C; Goodson, JM; Socransky, SS;
Indirizzi:
Forsyth Dent Ctr, Dept Periodontol, Boston, MA 02115 USA Forsyth Dent CtrBoston MA USA 02115 pt Periodontol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL PERIODONTOLOGY
fascicolo: 12, volume: 26, anno: 1999,
pagine: 775 - 783
SICI:
0303-6979(199912)26:12<775:SDAITT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED JUVENILE PERIODONTITIS; ACTINOMYCETEMCOMITANS-ASSOCIATED PERIODONTITIS; MUCOID PSEUDOMONAS-AERUGINOSA; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; REFRACTORY PERIODONTITIS; TOBRAMYCIN RESISTANCE; TETRACYCLINE THERAPY; ADULT PERIODONTITIS; IMMUNOLOGICAL FEATURES; TET(Q) GENE;
Keywords:
microbiology; bacteria; subgingival plaque; doxycycline; periodontal diseases; periodontitis; antibiotic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Haffajee, AD Forsyth Dent Ctr, Dept Periodontol, 140 Fenway, Boston, MA 02115 USA Forsyth Dent Ctr 140 Fenway Boston MA USA 02115 MA 02115 USA
Citazione:
M. Feres et al., "Systemic doxycycline administration in the treatment of periodontal infections - (I) - Effect on the subgingival microbiota", J CLIN PER, 26(12), 1999, pp. 775-783

Abstract

Systemic doxycycline is one of the more common antimicrobial agents used in the treatment of periodontal infections and yet little is known of its effect on subgingival plaque composition during and after its administration. The purpose of the present investigation was to evaluate changes in subgingival plaque composition during and after 14 days of doxycycline administration. 20 subjects with adult periodontitis were randomly assigned to test (n=10) and control (n=10) groups. The subjects received full mouth clinical assessment of pocket depth, attachment level, BOP, gingival redness, suppuration and plaque accumulation at baseline and 90 days. All subjects received full mouth SRP at baseline and, additionally, the test group received 100mg doxycycline daily for 14 days. Subgingival plaque samples were taken from the mesial surface of up to 28 teeth in each subject at baseline and 90 days. In addition, plaque samples were taken from 2 randomly selected teethat 3, 7 and 14 days during and after antibiotic administration. Control subjects were sampled at the same time points. Counts of 40 subgingival species were determined using checkerboard DNA-DNA hybridization and fluorescentdetection. Significance of differences between test and control groups wasdetermined at each time point using the Mann Whitney test. Significance ofchanges over time within test and control groups was determined using the Quade test. A modest but significant reduction in mean pocket depth from baseline to 90 days occurred in both test and control groups. A significant decrease in the % of sites with gingival redness occurred in the test group. There were no significant differences in proportions between test and control groups for 33 of the test species at any time point. Test subjects exhibited lower proportions of 4 Actinomyces species and an increase in 3 Streptococcus species during antibiotic administration. After cessation of doxycycline, Actinomyces sp. increased while Streptococcus sp. returned to baseline proportions. The relationship between these 2 genera appeared to be reciprocal; an increase in one was accompanied by a decrease in the other. Periodontal pathogens including B. forsythus, P. gingivalis, T. denticola and A. actinomycetemcomitans were not significantly altered by oral administration of doxycycline using conventional therapeutic dosage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:04:34