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Titolo:
Role of carcinoscorpin, a haemolymph lectin of horseshoe crab Carcinoscorpius rotundacauda as humoral factor
Autore:
Sarbadhikari, SB; Datta, D; Bhadra, R;
Indirizzi:
Indian Inst Chem Biol, Dept Cellular Biochem, Calcutta 700032, W Bengal, India Indian Inst Chem Biol Calcutta W Bengal India 700032 032, W Bengal, India Indian Assoc Cultivat Sci, Calcutta 700032, W Bengal, India Indian Assoc Cultivat Sci Calcutta W Bengal India 700032 W Bengal, India
Titolo Testata:
JOURNAL OF BIOSCIENCES
fascicolo: 4, volume: 24, anno: 1999,
pagine: 471 - 476
SICI:
0250-5991(199912)24:4<471:ROCAHL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOMBYX-MORI; HEMOLYMPH; PROTEIN; PHAGOCYTOSIS; MECHANISMS; MOLECULES; SILKWORM; INSECTS; SURFACE;
Keywords:
horseshoe crab; lectin induction; pathogen opsonization; higher host defence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bhadra, R Indian Inst Chem Biol, Dept Cellular Biochem, 4 Raja Sc Mullick Rd, Calcutta 700032, W Bengal, India Indian Inst Chem Biol 4 Raja Sc Mullick Rd Calcutta W Bengal India 700032
Citazione:
S.B. Sarbadhikari et al., "Role of carcinoscorpin, a haemolymph lectin of horseshoe crab Carcinoscorpius rotundacauda as humoral factor", J BIOSCI, 24(4), 1999, pp. 471-476

Abstract

This study demonstrated that a marine Indian horseshoe crab, Carcinoscorpious rotundacauda showed higher self defence in an experimental infection upon the induction of its circulatory lectin, carcinoscorpin. It resisted an infection with 10(7) live Escherichia coli per crab when the circulatory carcinoscorpin was 8-16-fold higher after administering 2-ketodeoxyoctonate (Kdo) into the live crab. The naive control with its natural level of circulatory lectin could tolerate a maximum infective dose of 10(6) live E. coli per crab. Bacterial killing and phagocytic uptake in association with the isolated crab amoebocytes in an ex vivo system was considerably higher for the lectin opsonized E. coli compared to unopsonized samples. Carcinoscorpinis thus functionally an opsonin in the defence of the primitive marine arthropod, C. rotundacauda, like vertebrate antibody, a humoral factor involved in the defence of the host. The natural capacity for defending an infection with 10(6) live E. coli per crab suggested that the crabs in the naturalhabitat hardly face such an infection and is possibly one of the reasons for its survival over millions of yeats as a living fossil.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:53:56