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Titolo:
A mutation in the 3-phosphoglycerate kinase gene allows anaerobic growth of Bacillus subtilis in the absence of ResE kinase
Autore:
Nakano, MM; Zhu, Y; Haga, K; Yoshikawa, H; Sonenshein, AL; Zuber, P;
Indirizzi:
Oregon Grad Inst Sci & Technol, Dept Biochem & Mol Biol, Beaverton, OR 97006 USA Oregon Grad Inst Sci & Technol Beaverton OR USA 97006 erton, OR 97006 USA Louisiana State Univ, Med Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ol, Shreveport, LA 71130 USA Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA TuftsUniv Boston MA USA 02111 Mol Biol & Microbiol, Boston, MA 02111 USA
Titolo Testata:
JOURNAL OF BACTERIOLOGY
fascicolo: 22, volume: 181, anno: 1999,
pagine: 7087 - 7097
SICI:
0021-9193(199911)181:22<7087:AMIT3K>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL PHOSPHATE SYNTHESIS; ESCHERICHIA-COLI; SURFACTIN PRODUCTION; SRFA OPERON; COMPETENCE; ACTIVATION; SEQUENCE; IDENTIFICATION; SPORULATION; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nakano, MM Oregon Grad Inst Sci & Technol, Dept Biochem & Mol Biol, 20,000NW Walker Rd, Beaverton, OR 97006 USA Oregon Grad Inst Sci & Technol 20,000 NW Walker Rd Beaverton OR USA 97006
Citazione:
M.M. Nakano et al., "A mutation in the 3-phosphoglycerate kinase gene allows anaerobic growth of Bacillus subtilis in the absence of ResE kinase", J BACT, 181(22), 1999, pp. 7087-7097

Abstract

The Bacillus subtilis ResD-ResE two-component signal transduction system is essential for aerobic and anaerobic respiration. A spontaneous suppressormutant that expresses ResD-controlled genes and grows anaerobically in theabsence of the ResE histidine kinase was isolated. In addition, aerobic expression of ResD-controlled genes in the suppressed strain was constitutiveand occurred at a much higher level than that observed in the wild-type strain. The suppressing mutation, which mapped to pgk, the gene encoding 3-phosphoglycerate kinase, failed to suppress a resD mutation, suggesting that the suppressing mutation creates a pathway far phosphorylation of the response regulator, ResD, which is independent of the cognate sensor kinase, ResE. The pgk-1 mutant exhibited very low but measurable 3-phosphoglycerate kinase activity compared to the,wild-type strain. The results suggest that accumulation of a glycolytic intermediate, probably 1,3-diphosphoglycerate, is responsible for the observed effect of the pgk-1 mutation on anaerobiosisof resE mutant cells.

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Documento generato il 25/11/20 alle ore 04:11:58