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Titolo:
Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization
Autore:
Nagashima, J; Okuda, K; Tanaka, M; Sata, M; Aoyagi, S;
Indirizzi:
Kurume Univ, Sch Med, Dept Surg 2, Div Hepatobiliary Pancreat Surg, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 Pancreat Surg, Fukuoka 8300011, Japan Kurume Univ, Sch Med, Dept Internal Med 2, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 Internal Med 2, Fukuoka 8300011, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 15, anno: 1999,
pagine: 1117 - 1123
SICI:
1019-6439(199912)15:6<1117:PBICSF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTRIC OCCURRENCE; REDUCTION SURGERY; HEPATIC RESECTION; LIVER-CANCER; PORTAL-VEIN; CHEMOTHERAPY; CISPLATIN; 5-FLUOROURACIL; EMBOLIZATION; INFUSION;
Keywords:
hepatocellular carcinoma; cytoreductive surgery; transcatheter arterial chemoembolization; hepatic arterial chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nagashima, J Kurume Univ, Sch Med, Dept Surg 2, Div Hepatobiliary PancreatSurg, 67 Asahimachi, Fukuoka 8300011, Japan Kurume Univ 67 Asahimachi Fukuoka Japan 8300011 00011, Japan
Citazione:
J. Nagashima et al., "Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization", INT J ONCOL, 15(6), 1999, pp. 1117-1123

Abstract

As a strategy for treating advanced hepatocellular carcinoma (HCC), cytoreductive surgery was studied comparing to transcatheter arterial chemoembolization (TACE). Patients who had curatively unresectable intrahepatic multiple HCC with the main tumor 30 mm or more in size were selected for this study. The patients were classified into two groups; i) cytoreductive surgery group (CRS group): 28 patients in whom the main tumor was resected but other cancer nodules remained in the remnant liver, ii) TACE group: 25 patientsat Child A grade who underwent TACE, and in whom it was also evaluated retrospectively that the main tumor had been resectable. The cumulative 5-yearsurvival rate was significantly higher in CRS (48.7%) than TACE (17.1%) group. Multivariate analysis revealed that performing cytoreductive surgery was a significant and independent factor to prolong survival. However, 6 of 28 patients died within one year of surgery. Residual tumor thrombus, and the absence or non-effectiveness of adjuvant therapy were significant high risk factors for postoperative death within one year. Conclusively, cytoreductive surgery contributes to a significant lengthening of survival in patients with advanced HCC. To reduce the risk of early postoperative death, theimportance of postoperative adjuvant therapy is also recognized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:07:03