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Titolo:
NONINVASIVE GRADING OF PRIMARY BRAIN-TUMORS - RESULTS OF A COMPARATIVE-STUDY BETWEEN SPET WITH I-123 ALPHA-METHYL TYROSINE AND PET WITH F-18 DEOXYGLUCOSE
Autore:
WOESLER B; KUWERT T; MORGENROTH C; MATHEJA P; PALKOVIC S; SCHAFERS M; VOLLET B; SCHAFERS K; LERCH H; BRANDAU W; SAMNICK S; WASSMANN H; SCHOBER O;
Indirizzi:
UNIV MUNSTER,DEPT NUCL MED,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NUCL MED D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NEUROSURG D-4400 MUNSTER GERMANY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 4, volume: 24, anno: 1997,
pagine: 428 - 434
SICI:
0340-6997(1997)24:4<428:NGOPB->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; CEREBRAL GLIOMAS; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; L-METHIONINE; FDG-PET; TUMORS; SURVIVAL; PERFORMANCE; PREDICTION;
Keywords:
BRAIN NEOPLASMS; POSITRON EMISSION TOMOGRAPHY; SINGLE-PHOTON EMISSION TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; IODINE-123-ALPHA-METHYL TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
B. Woesler et al., "NONINVASIVE GRADING OF PRIMARY BRAIN-TUMORS - RESULTS OF A COMPARATIVE-STUDY BETWEEN SPET WITH I-123 ALPHA-METHYL TYROSINE AND PET WITH F-18 DEOXYGLUCOSE", European journal of nuclear medicine, 24(4), 1997, pp. 428-434

Abstract

Use of iodine-123-alpha-melhyl tyrosine (I-123-IMT) allows investigation of the amino acid transport rate in gliomas. It was the aim of this study to compare the value of measurement of glucose metabolism withthat of measurement of I-123-IMT uptake for the non-invasive grading of brain tumours. The study population comprised 23 patients with histopathologically proven primary brain tumours, 14 had high-grade gliomas, and nine low-grade brain neoplasms, Glucose metabolism was studied using an ECAT EXACT 47 positron emission tomography (PET) camera and fluorine-18 fluorodeoxyglucose (F-18-FDG); I-123-IMT uptake was measured with the triple-headed single-photon emission tomography (SPET) camera, MULTISPECT 3. F-18-FDG and I-123-IMT uptake was quantified as ratios between the uptake by the tumour and contralateral regions of reference. Glucose metabolism and amino acid uptake of the brain tumours correlated significantly (r = 0.71, P < 0.001). Assuming discrimination thresholds between high-grade and low-grade tumours of 0.8 for F-18-FDG uptake and 1.8 for I-123-IMT uptake, the accuracy values of F-18-FDGPET and I-123-IMT SPET for differentiating between high-grade and low-grade rumours were 21/23 (91%) and 19/23 (83%), respectively. The difference in diagnostic performance was not significant on receiver operating characteristic analysis (P > 0.4). It is concluded that there isno major difference between the PET investigation of glucose metabolism and the less expensive SPET measurement of amino acid uptake in terms of their accuracy in evaluating the malignancy grade of primary brain tumours, This encourages the performance of further studies to analyse the potential impact of I-123-IMT SPET on the therapeutic management of patients with brain tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 05:20:13