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Titolo:
RELATIONSHIP BETWEEN CLINICAL-FEATURES OF PARKINSONS-DISEASE AND PRESYNAPTIC DOPAMINE TRANSPORTER BINDING ASSESSED WITH [I-123] IPT AND SINGLE-PHOTON EMISSION TOMOGRAPHY
Autore:
TATSCH K; SCHWARZ J; MOZLEY PD; LINKE R; POGARELL O; OERTEL WH; FIEBER RS; HAHN K; KUNG HF;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NUCL MED,MARCHIONINISTR 15 D-81377 MUNICH GERMANY UNIV MUNICH,DEPT NEUROL D-8000 MUNICH GERMANY UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104 UNIV PENN,DEPT PSYCHIAT PHILADELPHIA PA 19104
Titolo Testata:
European journal of nuclear medicine
fascicolo: 4, volume: 24, anno: 1997,
pagine: 415 - 421
SICI:
0340-6997(1997)24:4<415:RBCOPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; HEALTHY-HUMAN SUBJECTS; LIVING HUMAN BRAIN; LABELED 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; MONOAMINE TRANSPORTERS; NONHUMAN-PRIMATES; F-18 DOPA; SPECT; SYSTEM; PET;
Keywords:
DOPAMINE TRANSPORTER; COCAINE ANALOGS; SINGLE-PHOTON EMISSION TOMOGRAPHY; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Tatsch et al., "RELATIONSHIP BETWEEN CLINICAL-FEATURES OF PARKINSONS-DISEASE AND PRESYNAPTIC DOPAMINE TRANSPORTER BINDING ASSESSED WITH [I-123] IPT AND SINGLE-PHOTON EMISSION TOMOGRAPHY", European journal of nuclear medicine, 24(4), 1997, pp. 415-421

Abstract

IPT [N-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane] is a new cocain analogue which allows the presynaptic dopamine transporters to be imaged with single-photon emission tomography (SPET) as early as 1-2 h post injection. In the present study [I-123]IPT SPET was performed in patients with Parkinson's disease (PD) to analyse the relationship between specific dopamine tansporter binding and clinical features of the disease. Twenty-six PD patients (Hoehn and Yahr stages I-IV, age range 40-79 years) and eight age-matched controls were studied. SPET imaging was performed 90-120 min after injection of160-185 MBq [I-123]IPT using a triple-head camera. For semiquantitative evaluation of specific [I-123]IPT binding, ratios between caudate, putamen and background regions were calculated, Specific [I-123]IPT uptake was significantly reduced in PD patients compared to controls, Most patients showed a marked asymmetry with a more pronounced decrease in [I-123]IPT binding on the side contralateral to the predominant clinical findings. The putamen was always more affected than the caudate.[I-123]IPT binding was significantly correlated with disease duration(r = -0.7, P < 0.0001) but not with the age of PD patients (r = -0.10, P = 0.61). Specific [I-123]IPT uptake in the caudate and putamen, and putamen to caudate ratios, decreased with increasing Hoehn and Yahr stage. Our findings indicate that [I-123]IPT SPET may be a useful technique to estimate the extent of nigrostriatal degeneration in PD patients. Close relationships between striatal [I-123]IPT binding and clinical features of the disease suggest that this method can be used to objectively follow the course and progression of PD, The reduced putamento caudate ratios observed even in patients with mild, newly recognized symptoms indicate that particularly this parameter may help to establish the correct diagnosis in the early course of PD.

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Documento generato il 23/01/20 alle ore 19:27:58