Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RADIOIMMUNOSCINTIGRAPHY IN PATIENTS WITH BREAST ADENOCARCINOMA USING TC-99M LABELED MONOCLONAL-ANTIBODY 170H.82 - REPORT OF A PHASE-II STUDY
Autore:
MCQUARRIE SA; MACLEAN GD; BONIFACE GR; GOLBERG K; MCEWAN AJB;
Indirizzi:
CROSS CANC INST,DEPT ONCOL IMAGING,11560 UNIV AVE EDMONTON AB T6G 1Z2CANADA CROSS CANC INST,DEPT ONCOL IMAGING EDMONTON AB T6G 1Z2 CANADA UNIV ALBERTA EDMONTON AB CANADA BIOMIRA INC EDMONTON AB CANADA
Titolo Testata:
European journal of nuclear medicine
fascicolo: 4, volume: 24, anno: 1997,
pagine: 381 - 389
SICI:
0340-6997(1997)24:4<381:RIPWBA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CANCER; MASSES; CARCINOMA; EPIDEMIOLOGY; SCINTIGRAPHY; MAMMOGRAPHY; THERAPY; TUMORS;
Keywords:
RADIOIMMUNOSCINTIGRAPHY; MONOCLONAL ANTIBODY; BREAST ADENOCARCINOMA; RADIATION DOSIMETRY; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Mcquarrie et al., "RADIOIMMUNOSCINTIGRAPHY IN PATIENTS WITH BREAST ADENOCARCINOMA USING TC-99M LABELED MONOCLONAL-ANTIBODY 170H.82 - REPORT OF A PHASE-II STUDY", European journal of nuclear medicine, 24(4), 1997, pp. 381-389

Abstract

Fifty-three women with clinical evidence of adenocarcinoma of the breast were studied with technetium-99m labelled monoclonal antibody (MAb) 170H.82 at protein doses of 1, 2 and 4 mg. An overall per lesion efficacy of 83.5% sensitivity and 97.7% positive predictive value was obtained, Efficacy appears higher in lesions restricted to the breast andlocal regional disease than systemic metastases. For the 2 mg dose the breast/local regional disease efficacy was 90% sensitivity and 90.2%positive predictive value. The biodistribution of this MAb was best represented by a two-compartment model with a distribution-phase half-life of 4.0 +/- 1.4 h, followed by an elimination-phase half-life of 39.6 +/- 6.6 h. In all six patients studied, the critical organ was the kidney, with a mean radiation absorbed dose of 37 +/- 6.9 mGy/GBq, Theaccuracy of this imaging technique allows the development of diagnostic strategies for the routine use of the compound in patients with breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:32:50