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Titolo: Intermittent noise-induced hearing loss and the influence of carbon monoxide
Autore: Chen, GD; McWilliams, ML; Fechter, LD;
- Indirizzi:
- Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 arm, Oklahoma City, OK 73190 USA
- Titolo Testata:
- HEARING RESEARCH
fascicolo: 1-2,
volume: 138,
anno: 1999,
pagine: 181 - 191
- SICI:
- 0378-5955(199912)138:1-2<181:INHLAT>2.0.ZU;2-T
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- TEMPORARY THRESHOLD SHIFT; AUDITORY HAIR-CELLS; GUINEA-PIG; ACOUSTIC OVERSTIMULATION; RAT COCHLEA; EXPOSURE; CHINCHILLA; DAMAGE; OXYGEN; TRAUMA;
- Keywords:
- intermittent noise; noise-induced hearing loss; carbon monoxide; compound action potential; surface preparation; rat;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 40
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Chen, GD Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, 1110 N Stonewall, Oklahoma City, OK 73190 USA Univ Oklahoma 1110 N Stonewall Oklahoma City OK USA 73190 190 USA
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- Citazione:
- G.D. Chen et al., "Intermittent noise-induced hearing loss and the influence of carbon monoxide", HEARING RES, 138(1-2), 1999, pp. 181-191
Abstract
Intermittent noise causes less hearing loss than continuous noise of equalintensity. The reduction in damage observed with intermittent noise may beexplained by the fact that the auditory system has time to recover betweenthe noise phases. Simultaneous carbon monoxide (CO) exposure produces greater noise-induced hearing loss than does noise alone (Chen and Fechter, 1999). In the present study, intermittent noise (octave-band with a center frequency of 13.6 kHz, 100 dB) of a 2 h total duration but with a different duty cycle (% of noise during exposure) was used. The intermittent exposure that had a shorter noise duty cycle induced a less permanent threshold shift(PTS) than those that had a longer noise duty cycle (or less rest periods). This relation between the loss in compound action potential (CAP) sensitivity and the noise duty cycle (or rest period) was abolished by the presence of CO. The cochlear microphonic (CM) amplitude revealed similar results to those seen using the CAP. While intermittent noise that had a short noiseduty cycle did not cause hair cell loss by itself, the combined exposure to noise and CO (1200 ppm) caused remarkable OHC loss in the basal turn. (C)1999 Elsevier Science B.V. All rights reserved.
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Documento generato il 25/11/20 alle ore 19:03:44