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Titolo:
Invasive fetal therapy
Autore:
Paek, B; Strauss, A; Hasbargen, U; Hepp, H; Harrison, MR;
Indirizzi:
Univ Calif San Francisco, Fetal Treatment Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
GYNAKOLOGE
fascicolo: 11, volume: 32, anno: 1999,
pagine: 866 - 878
SICI:
0017-5994(199911)32:11<866:IFT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
GER
Soggetto:
CONGENITAL DIAPHRAGMATIC-HERNIA; CYSTIC ADENOMATOID MALFORMATION; EXTRACORPOREAL MEMBRANE-OXYGENATION; TO-HEAD RATIO; IN-UTERO; SACROCOCCYGEAL TERATOMA; TRACHEAL OCCLUSION; HYDRONEPHROSIS INUTERO; SPINA-BIFIDA; PULMONARY HYPOPLASIA;
Keywords:
fetal surgery; intrauterine therapy; fetoscopy; fetal anomaly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Strauss, A Univ Munich, Klinikum Grosshadern, Klin & Poliklin Frauenheilkunde & Geburtshilfe, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
B. Paek et al., "Invasive fetal therapy", GYNAKOLOGE, 32(11), 1999, pp. 866-878

Abstract

Although most prenatally diagnosed anatomic malformations are best managedafter birth, we can presently offer prenatal therapy to an increasing number of fetuses with simple anatomical defects that have predictably devastating developmental consequences. A condition amenable to prenatal intervention must fulfill a number of conditions. It must be severe enough to warrantthe risks associated with in utero treatment and must be reliably detectable before birth. Furthermore, the pathophysiology must be reversible by fetal intervention, significantly improving the prognosis over postnatal treatment. Current indication for prenatal intervention include decompression for obstructive uropathy, temporary tracheal occlusion for congenital diaphragmatic hernia, and tumor debulking for congenital cystic adenomatoid malformation of the lung and sacrococcygeal teratoma. Prenatal repair of myelomeningocele is currently being developed but remains controversial since this is not a lethal malformation. Maternal safety remains paramount in considering fetal intervention. The main associated risks are preterm labor and preterm premature rupture of membranes. To reduce maternal morbidity and the risk of prematurity, minimally invasive fetoscopic techniques were developedand are increasingly employed. These developments will in all probability reduce the importance of open fetal surgery in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:05:10