Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Power of concordant versus discordant sib pairs at different penetrance levels
Autore:
Nicolaou, M; Premkumar, S; DeStefano, AL; Farrer, LA; Cupples, LA;
Indirizzi:
Boston Univ, Sch Med, Dept Med, Genet Sect L320, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ed, Genet Sect L320, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Biostat & Epidemiol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Biostat & Epidemiol, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Boston, MA 02118 USABoston Univ Boston MA USA 02118 Biostat & Epidemiol, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA 02118 USA Boston UnivBoston MA USA 02118 l Hlth, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Publ Hlth, Dept Med, Boston, MA 02118 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 17, anno: 1999, supplemento:, 1
pagine: S679 - S684
SICI:
0741-0395(1999)17:<S679:POCVDS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; COMPLEX TRAITS;
Keywords:
concordant sib pairs; discordant sib pairs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolaou, M Boston Univ, Sch Med, Dept Med, Genet Sect L320, 715 Albany St, Boston, MA02118 USA Boston Univ 715 Albany St Boston MA USA 02118 ton, MA02118 USA
Citazione:
M. Nicolaou et al., "Power of concordant versus discordant sib pairs at different penetrance levels", GENET EPID, 17, 1999, pp. S679-S684

Abstract

Knowing the answers, we used the GAW11 data set to compare the power and efficiency of discordant versus concordant affected sib pairs for qualitative traits at different levels of penetrance. Samples of 200 concordant sib pairs outperformed discordant sib pairs for low penetrance (40%) and 70% penetrance models while at 90% penetrance they performed equally well. Increasing the sample size of discordant sib pairs to twice that of concordant pairs was not enough to reach the power of concordant sib pairs at the 40% and70% penetrance models. For low penetrance using a combination of concordant and discordant sib pairs resulted in higher power than using discordant sib pairs alone. At 90% penetrance, the power of concordant and discordant sib pairs was similar in the region close to the gene while concordant sib pairs performed better at locations further from the gene. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:32:29